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Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer

文献类型：期刊论文

作者Wang, Xiaoshuang8; Zhou, Yan6,7; Wu, Zhongen5; Xie, Cao4; Xu, Weiqi8; Zhou, Qingtong5; Yang, Dehua6,7; Zhu, Di2,3,5; Wang, Ming-Wei1; Wang, Lu8
刊名ISCIENCE
出版日期2024-02-16
卷号27期号:2页码:20
DOI10.1016/j.isci.2024.108896
通讯作者Zhu, Di(zhudifudan@163.com) ; Wang, Ming-Wei(mwwang@simm.ac.cn) ; Wang, Lu(cms024mm@163.com)
英文摘要Liver metastasis (LM) is the primary cause of cancer -related mortality in late -stage breast cancer (BC) patients. Here we report an in-depth analysis of the transcriptional landscape of LM of 11 patients with secondary hepatic carcinoma at single -cell resolution. Our study reveals that terminally exhausted CD4* and dysfunctional CD8* T cells were enriched in LM along with low antigen presentation. We also found that macrophages were associated with the tumor infiltrating CD4* T cells, while FCN3* macrophages, type 1 conventional dendritic cells (cDC1) and LAMP3* DC regulated T cell functions, probably via antigen processing and presentation. Major histocompatibility complex expression in FCN3* macrophage, cDC1 and LAMP3* DC was reduced in LM compared to those in normal tissues and primary BC. Malfunctioned antigen presentation in these cells is linked to a worse prognosis in invasive BC and hepatocellular carcinoma. Our results provide valuable insights into the role of tumor infiltrating T cells in LM.
WOS关键词HEPATIC STELLATE CELLS ; SINUSOIDAL ENDOTHELIAL-CELLS ; MATURATION ; TOLERANCE
资助项目National Natural Science Foundation of China[81872895] ; National Natural Science Foundation of China[82073881] ; National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[82073904] ; National Natural Science Foundation of China[82011530150] ; Shanghai Municipal Education Commission[DGF817029-04] ; Shanghai Science and Technology Commission[18ZR1403900] ; Shanghai Science and Technology Commission[20430713600] ; Shanghai Science and Technology Commission[18JC1413800] ; Fudan-SIMM Joint Research Fund[FU-SIMM20181010]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001175708100001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/310121]  
专题中国科学院上海药物研究所
通讯作者Zhu, Di; Wang, Ming-Wei; Wang, Lu
作者单位1.Res Ctr Deepsea Bioresources, Sanya 572025, Hainan, Peoples R China
2.Fudan Univ, Shanghai Med Coll, Shanghai 201100, Peoples R China
3.Fudan Univ, Minhang Hosp, Shanghai 201100, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Fudan Univ, Sch Basic Med Sci, Shanghai 200032, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
8.Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaoshuang,Zhou, Yan,Wu, Zhongen,et al. Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer[J]. ISCIENCE,2024,27(2):20.
APA Wang, Xiaoshuang.,Zhou, Yan.,Wu, Zhongen.,Xie, Cao.,Xu, Weiqi.,...&Wang, Lu.(2024).Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer.ISCIENCE,27(2),20.
MLA Wang, Xiaoshuang,et al."Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer".ISCIENCE 27.2(2024):20.

入库方式： OAI收割

来源：上海药物研究所

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