Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects
文献类型：期刊论文
| 作者 | Guan, Dezhong3; Fang, Lincheng1; Feng, Mingshun2; Guo, Shi4; Xie, Lingfeng4; Chen, Chao4; Sun, Xue3; Wu, Qingyun4; Yuan, Xinrui4; Xie, Zuoquan2
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| 出版日期 | 2024-03-05 |
| 卷号 | 267页码:13 |
| 关键词 | ENPP1 inhibitors cGAS-STING pathway 2 ', 3 '-cGAMP Tumor immunotherapy |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2024.116211 |
| 通讯作者 | Xie, Zuoquan(zqxie@simm.ac.cn) ; Zhou, Jinpei(zhjp@cpu.edu.cn) ; Zhang, Huibin(zhanghb80@cpu.edu.cn) |
| 英文摘要 | The cancer immunotherapies involved in cGAS-STING pathway have been made great progress in recent years. STING agonists exhibit broad-spectrum anti-tumor effects with strong immune response. As a negative regulator of the cGAS-STING pathway, ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) can hydrolyze extracellular 2 ', 3 '-cGAMP and reduce extracellular 2 ', 3 '-cGAMP concentration. ENPP1 has been validated to play important roles in diabetes, cancers, and cardiovascular disease and now become a promising target for tumor immunotherapy. Several ENPP1 inhibitors under development have shown good anti-tumor effects alone or in combination with other agents in clinical and preclinical researches. In this review, the biological profiles of ENPP1 were described, and the structures and the structure-activity relationships (SAR) of the known ENPP1 inhibitors were summarized. This review also provided the prospects and challenges in the development of ENPP1 inhibitors. |
| WOS关键词 | INSULIN-RECEPTOR INHIBITOR ; ANTICANCER AGENT SULOFENUR ; CANCER ; ENPP1 ; NPP1 ; DERIVATIVES ; MEMBRANE ; POTENT ; RAT ; MINERALIZATION |
| 资助项目 | Lingang Laboratory[LG202103-02-08] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001188018700001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310384]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Zuoquan; Zhou, Jinpei; Zhang, Huibin |
| 作者单位 | 1.Peking Univ, Shenzhen Grad Sch, Shenzhen, Peoples R China 2.Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.China Pharmaceut Univ, Dept Med Chem, Tongjiaxiang 24, Nanjing 210009, Peoples R China 4.China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Dezhong,Fang, Lincheng,Feng, Mingshun,et al. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2024,267:13. |
| APA | Guan, Dezhong.,Fang, Lincheng.,Feng, Mingshun.,Guo, Shi.,Xie, Lingfeng.,...&Zhang, Huibin.(2024).Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,267,13. |
| MLA | Guan, Dezhong,et al."Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 267(2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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