Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD
文献类型：期刊论文
| 作者 | Shi, Rui6; Liang, Renwen5; Wang, Fang4; Wang, Lueli6; Zidai, Wuyi6; Zhang, Jie6; Min, Luo6; Du, Xiaohua3; Sun, Shibo2; Xiao, Chuang6 |
| 刊名 | APOPTOSIS
 |
| 出版日期 | 2024-04-23 |
| 页码 | 17 |
| 关键词 | COPD PANoptosis PYCARD Immune infiltration Inflammation |
| ISSN号 | 1360-8185 |
| DOI | 10.1007/s10495-024-01961-6 |
| 通讯作者 | Liang, Xuewu(liangxuewu0714@simm.ac.cn) ; Chen, Alex F.(chenfengyuan@xinhuamed.com.cn) ; Yang, Weimin(yangweimin@kmmu.edu.cn) |
| 英文摘要 | Chronic inflammatory and immune responses play key roles in the development and progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique inflammatory cell death modality, is involved in the pathogenesis of many inflammatory diseases. We aim to identify critical PANoptosis-related biomarkers and explore their potential effects on respiratory tract diseases and immune infiltration landscapes in COPD. Total microarray data consisting of peripheral blood and lung tissue datasets associated with COPD were obtained from the GEO database. PANoptosis-associated genes in COPD were identified by intersecting differentially expressed genes (DEGs) with genes involved in pyroptosis, apoptosis, and necroptosis after normalizing and removing the batch effect. Furthermore, GO, KEGG, PPI network, WGCNA, LASSO-COX, and ROC curves analysis were conducted to screen and verify hub genes, and the correlation between PYCARD and infiltrated immune cells was analyzed. The effect of PYCARD on respiratory tract diseases and the potential small-molecule agents for the treatment of COPD were identified. PYCARD expression was verified in the lung tissue of CS/LPS-induced COPD mice. PYCARD was a critical PANoptosis-related gene in all COPD patients. PYCARD was positively related to NOD-like receptor signaling pathway and promoted immune cell infiltration. Moreover, PYCARD was significantly activated in COPD mice mainly by targeting PANoptosis. PANoptosis-related gene PYCARD is a potential biomarker for COPD diagnosis and treatment. |
| WOS关键词 | OBSTRUCTIVE PULMONARY-DISEASE ; RISK-FACTORS |
| 资助项目 | Yunnan Key Laboratory of Pharmacology for Natural Products |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001216620100001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310864]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liang, Xuewu; Chen, Alex F.; Yang, Weimin |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Dev & Regenerat Cardiovasc Med, Sch Med, Xinhua Hosp, Shanghai, Peoples R China 2.Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Kunming, Peoples R China 3.Kunming Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Kunming, Peoples R China 4.Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, Kunming, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 6.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Rui,Liang, Renwen,Wang, Fang,et al. Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD[J]. APOPTOSIS,2024:17. |
| APA | Shi, Rui.,Liang, Renwen.,Wang, Fang.,Wang, Lueli.,Zidai, Wuyi.,...&Yang, Weimin.(2024).Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD.APOPTOSIS,17. |
| MLA | Shi, Rui,et al."Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD".APOPTOSIS (2024):17. |
入库方式： OAI收割
来源：上海药物研究所
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