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Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography

文献类型：期刊论文

作者Li, Long5,6,7,8,9; Hou, Ruihan9; Shi, Xinghua4; Ji, Jing3; Rozycki, Bartosz2; Hu, Jinglei9; Song, Fan1,7,8; Song F(宋凡); Li L(李龙); Li L(李龙)
刊名COMMUNICATIONS PHYSICS
出版日期2024-06-01
卷号7期号:1页码:9
ISSN号2399-3650
DOI10.1038/s42005-024-01670-1
通讯作者Ji, Jing(09714@buaa.edu.cn) ; Rozycki, Bartosz(rozycki@ifpan.edu.pl) ; Hu, Jinglei(hujinglei@nju.edu.cn)
英文摘要Developing physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological and pathological processes as well as for stimulating novel therapeutic strategies. Here, we propose an effective means to control receptor condensation on the cell membrane via specific adhesion to a supported lipid bilayer (SLB) with nanoscale topography. The specific adhesion is mediated by receptors in the cell membrane that bind their ligands anchored in the SLB. Using Monte Carlo simulations and mean-field theory, we demonstrate that the nanoscale topography of the SLB can enhance condensation of the receptors associated with lipid nanodomains. Our results indicate that SLBs with nanoscale topography proves an effective physical stimulus for tuning condensation of membrane adhesion proteins and lipids in cell membranes, and can serve as a feasible option to control and direct cellular activities, e.g., stem cell differentiation for biomedical and therapeutic applications. Developing physical methods to modulate biomolecular condensates on cell membranes is of great importance for understanding physiological processes and stimulating novel therapeutic strategies. We propose an effective means to control receptor condensation on cell membranes via adhesion to a supported lipid bilayer with nanoscale topography.
WOS关键词LIPID RAFTS ; ANCHORED RECEPTORS ; PHASE-SEPARATION ; LIGAND BINDING ; E-SELECTIN ; AFFINITY ; COOPERATIVITY ; ORGANIZATION ; CONSTANT ; KINETICS
资助项目This research was funded by the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB0620101), the National Natural Science Foundation of China (Grant Nos. 22161132012, 12272388, 12232019, 21973040, 11902327, 11972041), the Nati[XDB0620101] ; Strategic Priority Research Program of Chinese Academy of Sciences[22161132012] ; Strategic Priority Research Program of Chinese Academy of Sciences[12272388] ; Strategic Priority Research Program of Chinese Academy of Sciences[12232019] ; Strategic Priority Research Program of Chinese Academy of Sciences[21973040] ; Strategic Priority Research Program of Chinese Academy of Sciences[11902327] ; Strategic Priority Research Program of Chinese Academy of Sciences[11972041] ; National Natural Science Foundation of China[2021/40/Q/NZ1/00017] ; National Science Centre of Poland ; Youth Innovation Promotion Association CAS
WOS研究方向Physics
语种英语
WOS记录号WOS:001236835700003
资助机构This research was funded by the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB0620101), the National Natural Science Foundation of China (Grant Nos. 22161132012, 12272388, 12232019, 21973040, 11902327, 11972041), the Nati ; Strategic Priority Research Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Science Centre of Poland ; Youth Innovation Promotion Association CAS
源URL[http://dspace.imech.ac.cn/handle/311007/95465]  
专题力学研究所_非线性力学国家重点实验室
通讯作者Ji, Jing; Rozycki, Bartosz; Hu, Jinglei
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
2.Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, 02-668 Warsaw, Poland
3.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol,Minist Educ, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
5.Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou 510095, Peoples R China
6.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
8.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
9.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Li, Long,Hou, Ruihan,Shi, Xinghua,et al. Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography[J]. COMMUNICATIONS PHYSICS,2024,7(1):9.
APA Li, Long.,Hou, Ruihan.,Shi, Xinghua.,Ji, Jing.,Rozycki, Bartosz.,...&李龙.(2024).Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography.COMMUNICATIONS PHYSICS,7(1),9.
MLA Li, Long,et al."Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography".COMMUNICATIONS PHYSICS 7.1(2024):9.

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来源：力学研究所

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