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Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke

文献类型：期刊论文

作者Li W(李伟)5,6; Chong Li3,4,5; Aixian Liu2; Ping‑Ju Lin5; Linhong Mo2; Hongliang Zhao7; Quan Xu1,5; Xiangzun Meng5; Linhong Ji5
刊名Journal of NeuroEngineering and Rehabilitation
出版日期2023
卷号20期号:155页码:1-15
关键词Sensory stimulation
ISSN号无
DOI10.1186/s12984-023-01276-8 
文献子类SCI论文
英文摘要
Background Sensory stimulation can play a fundamental role in the activation of the primary sensorimotor cortex (S1‑M1), which can promote motor learning and M1 plasticity in stroke patients. However, studies have focused mainly on investigating the influence of brain lesion profiles on the activation patterns of S1‑M1 during motor tasks instead of sensory tasks. Therefore, the objective of this study is to explore the lesion‑specific activation patterns due to different brain lesion profiles and types during focal vibration (FV).Methods: In total 52 subacute stroke patients were recruited in this clinical experiment, including patients with basal ganglia hemorrhage/ischemia, brainstem ischemia, other subcortical ischemia, cortical ischemia, and mixed cortical–subcortical ischemia. Electroencephalograms (EEG) were recorded following a resting state lasting for 4 min and three sessions of FV. FV was applied over the muscle belly of the affected limb’s biceps for 3 min each session. Beta motor‑related EEG power desynchronization overlying S1‑M1 was used to indicate the activation of S1‑M1, while the laterality coefficient (LC) of the activation of S1‑M1 was used to assess the interhemispheric asymmetry of brain activation. Results (1) Regarding brain lesion profiles, FV could lead to the significant activation of bilateral S1‑M1 in patients with basal ganglia ischemia and other subcortical ischemia. The activation of ipsilesional S1‑M1 in patients with brain‑stem ischemia was higher than that in patients with cortical ischemia. No activation of S1‑M1 was observed in patients with lesions involving cortical regions. (2) Regarding brain lesion types, FV could induce the activation of bilateral S1‑M1 in patients with basal ganglia hemorrhage, which was significantly higher than that in patients with basal ganglia ischemia. Additionally, LC showed no significant correlation with the modified Barthel index (MBI) in all patients, but a positive correlation with MBI in patients with basal ganglia lesions. Conclusions These results reveal that sensory stimulation can induce lesion‑specific activation patterns of S1‑M1. This indicates FV could be applied in a personalized manner based on the lesion‑specific activation of S1‑M1 in stroke patients with different lesion profiles and types. Our study may contribute to a better understanding of the underlying mechanisms of cortical reorganization.
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WOS研究方向Engineering, Biomedical，Neurosciences，Rehabilitation
语种英语
CSCD记录号CSCD:无
WOS记录号WOS:001101617900001
出版者BioMed Central
源URL[http://ir.ia.ac.cn/handle/173211/57656]  
专题多模态人工智能系统全国重点实验室_医疗机器人
通讯作者Chong Li; Quan Xu
作者单位1.Department of Rehabilitation Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
2.Neurological Rehabilitation Center, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing, China
3.Medical Research Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China
4.School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China
5.Department of Mechanical Engineering, Tsinghua University, Haidian, Beijing, China
6.State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
7.Department of Radiology, Beijing Tsinghua Chang‑ gung Hospital, Tsinghua University, Beijing, China
推荐引用方式
GB/T 7714		 Li W,Chong Li,Aixian Liu,et al. Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke[J]. Journal of NeuroEngineering and Rehabilitation,2023,20(155):1-15.
APA Li W.,Chong Li.,Aixian Liu.,Ping‑Ju Lin.,Linhong Mo.,...&Linhong Ji.(2023).Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke.Journal of NeuroEngineering and Rehabilitation,20(155),1-15.
MLA Li W,et al."Lesion-specific cortical activation following sensory stimulation in patients with subacute stroke".Journal of NeuroEngineering and Rehabilitation 20.155(2023):1-15.

入库方式： OAI收割

来源：自动化研究所

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