Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity
文献类型：期刊论文
| 作者 | Al-Romaima,Abdulbaset; Hu,Guilin; Wang,Yanbing; Quan,Chenxi; Dai,Haopeng; Qiu,Minghua
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 72期号:3页码:1683-1694 |
| 关键词 | Coffeaarabica coffee pulp diterpenoids structure elucidation alpha-glucosidase moleculardocking ENT-KAURANE DITERPENES ACID PRODUCTS EXTRACTS CAFFEINE CAFESTOL ESTERS BEANS |
| ISSN号 | 1520-5118 |
| DOI | 10.1021/acs.jafc.3c05619 |
| 英文摘要 | Six new (1, 2, 3, 5, 6, and 8) and seven known (4, 7, 9, 10, 11, 12, and 13) diterpenoids have been identified in the pulp of Coffea arabica. The structures of new diterpenoids were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR (HSQC, HMBC, H-1-H-1 COSY, and ROESY), HRESIMS, IR, DP4+, electronic circular dichroism, and X-ray crystallography analysis. Compound 1 is ent-labdane-type diterpenoid, whereas compounds (2-13) are ent-kaurane diterpenoids. The result of alpha-glucosidase inhibitory assay demonstrated that compounds (1, 3, 5, 7, and 10) have moderate inhibitory activity with IC50 values of 55.23 +/- 0.84, 74.02 +/- 0.89, 66.46 +/- 1.05, 49.70 +/- 1.02, and 76.34 +/- 0.46 mu M, respectively, compared to the positive control (acarbose, 51.62 +/- 0.21 mu M). Furthermore, molecular docking analysis has been conducted to investigate the interaction between the compounds and the receptors of alpha-glucosidase to interpret their mechanism of activity. This study is the first investigation that successfully discovered the presence of diterpenoids within the coffee pulp. |
| 学科主题 | 342 |
| WOS记录号 | WOS:001150570700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75298]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Al-Romaima,Abdulbaset,Hu,Guilin,Wang,Yanbing,et al. Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,72(3):1683-1694. |
| APA | Al-Romaima,Abdulbaset,Hu,Guilin,Wang,Yanbing,Quan,Chenxi,Dai,Haopeng,&Qiu,Minghua.(2023).Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(3),1683-1694. |
| MLA | Al-Romaima,Abdulbaset,et al."Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.3(2023):1683-1694. |
入库方式： OAI收割
来源：昆明植物研究所
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