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Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study

文献类型：期刊论文

作者Li, Xingxing4,5,6; Liu, Junyao4,5; Wei, Shuochi6; Yu, Chang6; Wang, Dongmei4,5; Li, Yuchen6; Li, Jiaxin4,5; Zhuang, Wenhao6; Luo, Rui-Chen-Xi6; Li, Yanli6
刊名BMC MEDICINE
出版日期2024-06-20
卷号22期号:1页码:12
关键词Major depressive disorder rTMS tDCS Clinical trial Cognition
ISSN号1741-7015
DOI10.1186/s12916-024-03443-7
通讯作者Zhou, Dongsheng(wyzhouds@sina.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have been studied separately in the treatment of cognitive dysfunction in MDD patients. We aimed to investigate the effectiveness and safety of rTMS combined with tDCS as a new therapy to improve neurocognitive impairment in MDD patients. Methods In this brief 2-week, double-blind, randomized, and sham-controlled trial, a total of 550 patients were screened, and 240 MDD inpatients were randomized into four groups (active rTMS + active tDCS, active rTMS + sham tDCS, sham rTMS + active tDCS, sham rTMS + sham tDCS). Finally, 203 patients completed the study and received 10 treatment sessions over a 2-week period. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess patients' cognitive function at baseline and week 2. Also, we applied the 24-item Hamilton Depression Rating Scale (HDRS-24) to assess patients' depressive symptoms at baseline and week 2. Results After 10 sessions of treatment, the rTMS combined with the tDCS group showed more significant improvements in the RBANS total score, immediate memory, and visuospatial/constructional index score (all p < 0.05). Moreover, post hoc tests revealed a significant increase in the RBANS total score and Visuospatial/Constructional in the combined treatment group compared to the other three groups but in the immediate memory, the combined treatment group only showed a better improvement than the sham group. The results also showed the RBANS total score increased significantly higher in the active rTMS group compared with the sham group. However, rTMS or tDCS alone was not superior to the sham group in terms of other cognitive performance. In addition, the rTMS combined with the tDCS group showed a greater reduction in HDRS-24 total score and a better depression response rate than the other three groups. Conclusions rTMS combined with tDCS treatment is more effective than any single intervention in treating cognitive dysfunction and depressive symptoms in MDD patients.
收录类别SCI
WOS关键词TRANSCRANIAL MAGNETIC STIMULATION ; NONINVASIVE BRAIN-STIMULATION ; CORTICAL EXCITABILITY ; PREFRONTAL CORTEX ; MOTOR CORTEX ; EFFICACY ; SCHIZOPHRENIA ; METAANALYSIS ; COMBINATION ; MODULATION
资助项目Natural Science Foundation of Zhejiang Province[LQ21H170001] ; Basic Public Welfare Project of Zhejiang Province[LGF22H090055] ; Ningbo Medical and Health brand discipline[PPXK2024-07] ; Ningbo Clinical Medical Research Centre for Mental Health[2022L002] ; Ningbo Top Medical and Health Research Program[2022030410] ; Zhejiang Medical and Health Science and Technology Plan Project[2021KY331] ; Ningbo Natural Science Foundation of China[202003N4263] ; Ningbo Natural Science Foundation of China[2021J275] ; Ningbo Natural Science Foundation of China[2019A610298] ; Zhejiang Province Traditional Chinese Medicine Health Project[2021ZB266] ; Ningbo Public Welfare Science and Technology Plan Project[2021S180] ; Ningbo Medical Science and Technology Project[2019Y24] ; Ningbo Medical Science and Technology Project[2020Y19] ; Ningbo Medical Science and Technology Project[2021Y25] ; Lishui Public Welfare Technology Application Research Project[2022GYX46]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:001252151800001
出版者BMC
资助机构Natural Science Foundation of Zhejiang Province ; Basic Public Welfare Project of Zhejiang Province ; Ningbo Medical and Health brand discipline ; Ningbo Clinical Medical Research Centre for Mental Health ; Ningbo Top Medical and Health Research Program ; Zhejiang Medical and Health Science and Technology Plan Project ; Ningbo Natural Science Foundation of China ; Zhejiang Province Traditional Chinese Medicine Health Project ; Ningbo Public Welfare Science and Technology Plan Project ; Ningbo Medical Science and Technology Project ; Lishui Public Welfare Technology Application Research Project
源URL[http://ir.psych.ac.cn/handle/311026/48362]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhou, Dongsheng; Zhang, Xiangyang
作者单位1.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA
2.Taizhou Second Peoples Hosp, Taizhou, Zhejiang, Peoples R China
3.Second Peoples Hosp Lishui, Dept Geriatr, Lishui, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
6.Ningbo Univ, Ningbo Kangning Hosp, Ningbo Key Lab Phys Diag & Treatment Mental & Psyc, Affiliated Kangning Hosp, Ningbo, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xingxing,Liu, Junyao,Wei, Shuochi,et al. Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study[J]. BMC MEDICINE,2024,22(1):12.
APA Li, Xingxing.,Liu, Junyao.,Wei, Shuochi.,Yu, Chang.,Wang, Dongmei.,...&Zhang, Xiangyang.(2024).Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study.BMC MEDICINE,22(1),12.
MLA Li, Xingxing,et al."Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study".BMC MEDICINE 22.1(2024):12.

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来源：心理研究所

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