Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes
文献类型：期刊论文
| 作者 | Wang,Qian; Hu,Guilin; Lu,Qian; Hong,Defu; Al-Romaima,Abdulbaset; Qiu,Minghua ; Xiong,Wenyong
|
| 刊名 | FOOD & FUNCTION
 |
| 出版日期 | 2023 |
| 卷号 | 14期号:11页码:5138-5150 |
| 关键词 | ACCUMULATION CAFESTOL KAHWEOL BEANS DIFFERENTIATION |
| ISSN号 | 2042-650X |
| DOI | 10.1039/d3fo01130e |
| 英文摘要 | Previous studies have shown that coffee has a role in regulating lipid metabolism. However, the active compounds and pharmacological mechanism(s) are still unclear. Here, four new coffee diterpenoids (1-4) were identified from roasted arabica coffee (Coffea arabica L.) beans, and together with 31 known coffee diterpenoids (5-35), their bioactivities in the regulation of lipid content in white adipocytes were evaluated. Based on their structures and correlated bioactivities, we proposed that the alpha,beta-unsaturated-gamma-lactone moiety and hydroxyl group at C-3 are required for the bioactivity. Furthermore, the pharmacological approaches revealed that the active new diterpenoid, dehydrocaffarolide B, inhibited the Akt/mTOR/GSK3 beta pathway and arrested cells in the G0/G1 phase of the mitotic clonal expansion process during the adipocyte differentiation and maturation, eventually resulting in the blunting of lipid accumulation in the adipocytes. Collectively, our findings identified four new diterpenoids of arabica coffee and elucidated a mechanism of an active lactone-type diterpenoid in the regulation of lipid content in white adipocytes. |
| 学科主题 | Biochemistry & Molecular Biology ; Food Science & Technology |
| WOS记录号 | WOS:000986884400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75616]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang,Qian,Hu,Guilin,Lu,Qian,et al. Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes[J]. FOOD & FUNCTION,2023,14(11):5138-5150. |
| APA | Wang,Qian.,Hu,Guilin.,Lu,Qian.,Hong,Defu.,Al-Romaima,Abdulbaset.,...&Xiong,Wenyong.(2023).Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes.FOOD & FUNCTION,14(11),5138-5150. |
| MLA | Wang,Qian,et al."Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytes".FOOD & FUNCTION 14.11(2023):5138-5150. |
入库方式： OAI收割
来源：昆明植物研究所
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