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V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor

文献类型：期刊论文

作者Yun, Ying1,2,3; Guo, Shimeng2; Xie, Xin1,2,3
刊名CELL AND BIOSCIENCE
出版日期2024-08-31
卷号14期号:1页码:11
关键词Arginine vasopressin Insulin Glucagon V1bR GLP-1R Islets Diabetes
DOI10.1186/s13578-024-01288-4
通讯作者Xie, Xin(xxie@simm.ac.cn)
英文摘要BackgroundArginine vasopressin (AVP) has been reported to regulate insulin secretion and glucose homeostasis in the body. Previous study has shown that AVP and its receptor V1bR modulate insulin secretion via the hypothalamic-pituitary-adrenal axis. AVP has also been shown to enhance insulin secretion in islets, but the exact mechanism remains unclear.ResultsIn our study, we unexpectedly discovered that AVP could only stimulates insulin secretion from islets, but not beta cells, and AVP-induced insulin secretion could be blocked by V1bR selective antagonist. Single-cell transcriptome analysis identified that V1bR is only expressed by the alpha cells. Further studies indicated that activation of the V1bR stimulates the alpha cells to secrete glucagon, which then promotes glucose-dependent insulin secretion from beta cells in a paracrine way by activating GLP-1R but not GCGR on these cells.ConclusionsOur study revealed a crosstalk between alpha and beta cells initiated by AVP/V1bR and mediated by glucagon/GLP-1R, providing a mechanism to develop new glucose-controlling therapies targeting V1bR.
WOS关键词VASOPRESSIN RECEPTOR ; ARGININE-VASOPRESSIN ; BETA ; RELEASE ; CELLS ; ANTAGONIST ; PHYSIOLOGY ; OXYTOCIN ; STRESS ; ISLETS
资助项目National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[82304579] ; National Natural Science Foundation of China[82330113] ; Taishan Scholars Program
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:001302496500001
出版者BMC
源URL[http://119.78.100.183/handle/2S10ELR8/313077]  
专题新药研究国家重点实验室
通讯作者Xie, Xin
作者单位1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shou Jing Rd, Shanghai 201203, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Peoples R China
推荐引用方式
GB/T 7714		 Yun, Ying,Guo, Shimeng,Xie, Xin. V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor[J]. CELL AND BIOSCIENCE,2024,14(1):11.
APA Yun, Ying,Guo, Shimeng,&Xie, Xin.(2024).V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor.CELL AND BIOSCIENCE,14(1),11.
MLA Yun, Ying,et al."V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor".CELL AND BIOSCIENCE 14.1(2024):11.

入库方式： OAI收割

来源：上海药物研究所

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