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Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading

文献类型：期刊论文

作者Ye, Zeng10,11,12,13,14; Zhou, Yan9; Hu, Yuheng8; Li, Qiang7; Xu, Zijin6; Lou, Xin10,11,12,13,14; Zhang, Wuhu10,11,12,13,14; Zhu, Di5; Xie, Cao4; Zhou, Qingtong3,5
刊名ISCIENCE
出版日期2024-09-20
卷号27期号:9页码:18
关键词tumor cells CNV neutral tumor cells neuroendocrine cells profile
DOI10.1016/j.isci.2024.110836
通讯作者Chen, Jie(chenjiec@fudanpci.org) ; Ji, Shunrong(jishunrongc@fudanpci.org) ; Wang, Ming-Wei(mwwangc@simm.ac.cn) ; Yu, Xianjun(yuxianjunc@fudanpci.org)
英文摘要Histological grading is the key factors affecting the prognosis and instructive in guiding treatment and assessing recurrence in non-functional pancreatic neuroendocrine tumor (NF-Pan-NET). Approximately one-third of patients without copy number variation (CNV) alteration and the prognosis of these patients are better than that of patients with CNV alteration. However, the difference between CNV and histological grading is unclear. Here, we analyzed the heterogeneity of tumor cells according to two classification criteria, genomic instability (including CNV alteration and tumor mutation burden) and histological grading. We revealed that the activated core pathways of tumor cells were significantly different under different histological grading's and genomic instability patterns. We also found that tip cells, lymphatic endothelial cells, macrophages, CD1A + dendritic cell, Treg, MAIT, ILC, and CAFs might participate in the process of hepatic metastases, which will facilitate the understanding of the patterns to decode the malignant potential and of NF-Pan-NET.
WOS关键词LANDSCAPE
资助项目National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[82073904] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[81973373] ; National Natural Science Foundation of China[21704064] ; National Natural Science Foundation of China[82141129] ; National Natural Science Foundation of China[82141104] ; National Natural Science Foundation of China[U21A20374] ; National Natural Science Foundation of China[82303943] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2018ZX09735-001] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2018ZX09711002-002-005] ; National Key Basic Research Program of China[2018YFA0507000] ; Shanghai Municipal Education Commission-Shanghai Top-Level University Capacity Building Program[DGF817029-04] ; Hainan Provincial Major Science and Technology Project[ZDKJ2021028] ; Shanghai Municipality Science and Technology Development Fund[21JC1401600] ; Shanghai Municipal Science and Technology Major Project[21JC1401500] ; Scientific Innovation Project of Shanghai Education Committee[2019-01-07-00-07-E00057] ; Clinical Research Plan of Shanghai Hospital Development Center[SHDC2020CR1006A] ; Xuhui District Artificial Intelligence Medical Hospital Cooperation Project[23YF1406900] ; Sailing Project of Science and Technology Commission of Shanghai Municipality ; China Postdoctoral Science Foundation[2023M730670] ; [2021-011]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001318568000001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/313636]  
专题中国科学院上海药物研究所
通讯作者Chen, Jie; Ji, Shunrong; Wang, Ming-Wei; Yu, Xianjun
作者单位1.Univ Tokyo, Sch Sci, Dept Chem, Tokyo 1130033, Japan
2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Res Ctr Deepsea Bioresources, Sanya 572025, Hainan, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Fudan Univ, Sch Basic Med Sci, Dept Pharmacol, Shanghai 200032, Peoples R China
6.Zhongshan Hosp, Gen Surg Dept, Qingpu Branch, Shanghai 200032, Peoples R China
7.Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, D-1581377 Munich, Germany
8.Tongji Univ, Peoples Hosp 10, Sch Med, Dept Hepatobiliary & Pancreat Surg, Shanghai, Peoples R China
9.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
10.Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Zeng,Zhou, Yan,Hu, Yuheng,et al. Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading[J]. ISCIENCE,2024,27(9):18.
APA Ye, Zeng.,Zhou, Yan.,Hu, Yuheng.,Li, Qiang.,Xu, Zijin.,...&Yu, Xianjun.(2024).Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading.ISCIENCE,27(9),18.
MLA Ye, Zeng,et al."Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading".ISCIENCE 27.9(2024):18.

入库方式： OAI收割

来源：上海药物研究所

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