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Synthesis and Biological Activity of Tetracyclic Dispiro Core Derivatives of Natural Products Dispirocochlearoids A-C

文献类型：期刊论文

作者Pei, Junping1,2; Wang, Ying2; Shi, Shengjie2; Chen, Linhai1,2; Yin, Jianpeng2; Nan, Fajun1,2
刊名ORGANIC LETTERS
出版日期2024-11-01
卷号26期号:45页码:9654-9658
ISSN号1523-7060
DOI10.1021/acs.orglett.4c03358
英文摘要Natural products dispirocochlearoids A-C, which are meroterpenoids derived from Ganoderma fungi, feature a 6/6/5/6/6/6 ring system and exhibit selective COX-2 inhibitory activity. Herein, the concise total synthesis of the tetracyclic core structure of dispirocochlearoids A-C was achieved through an aldol reaction/cyclization/deprotection/cyclization cascade sequence. A series of simplified tetracyclic analogues was successfully constructed and their anti-inflammatory activity was further explored, with several tetracyclic analogues (such as compound 8ab) exhibiting strong inhibitory activity against IL-1 beta expression in lipopolysaccharide-stimulated bone marrow-derived macrophage cells (IC50 = 2.8 mu M).
资助项目Natural Science Foundation of Shandong Province[2023YFA0915800] ; National Key Research and Development Program of China[ZR2023QH355] ; Shandong Provincial Natural Science Foundation
WOS研究方向Chemistry
WOS记录号WOS:001346994800001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/314388]  
专题新药研究国家重点实验室
通讯作者Nan, Fajun
作者单位1.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Pei, Junping,Wang, Ying,Shi, Shengjie,et al. Synthesis and Biological Activity of Tetracyclic Dispiro Core Derivatives of Natural Products Dispirocochlearoids A-C[J]. ORGANIC LETTERS,2024,26(45):9654-9658.
APA Pei, Junping,Wang, Ying,Shi, Shengjie,Chen, Linhai,Yin, Jianpeng,&Nan, Fajun.(2024).Synthesis and Biological Activity of Tetracyclic Dispiro Core Derivatives of Natural Products Dispirocochlearoids A-C.ORGANIC LETTERS,26(45),9654-9658.
MLA Pei, Junping,et al."Synthesis and Biological Activity of Tetracyclic Dispiro Core Derivatives of Natural Products Dispirocochlearoids A-C".ORGANIC LETTERS 26.45(2024):9654-9658.

入库方式： OAI收割

来源：上海药物研究所

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