Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology
文献类型：期刊论文
| 作者 | Zhou, Qingtong8,9; Li, Guanyi7,8; Hang, Kaini9; Li, Jie; Yang, Dehua4,5,6,8 ; Wang, Ming-Wei1,2,3,5,6,8,9
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| 刊名 | ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
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| 出版日期 | 2025 |
| 卷号 | 65页码:191-213 |
| 关键词 | overweight glucagon-like peptide-1 receptor unimolecular polypharmacology tirzepatide retatrutide metabolic diseases |
| ISSN号 | 0362-1642 |
| DOI | 10.1146/annurev-pharmtox-061324-011832 |
| 通讯作者 | Wang, Ming-Wei(mwwang@simm.ac.cn) |
| 英文摘要 | Obesity and type 2 diabetes mellitus (T2DM) impact more than 2.5 billion molecular polypharmacology, which involves designing single molecules to target multiple receptors or pathways simultaneously, has revolutionized treatment strategies. Blockbuster drugs such as tirzepatide and retatrutide have shown unprecedented success in managing obesity and T2DM, demonstrating superior efficacy compared to conventional single agonists. Tirzepatide, in particular, has garnered tremendous attention for its remarkable effectiveness in promoting weight loss and improving glycemic control, while offering additional cardiovascular and renal benefits. Despite their promises, such therapeutic agents also face challenges that include gastrointestinal side effects, patient compliance issues, and body weight rebound after cessation of the treatment. Nonetheless, the development of these therapies marks a significant leap forward, underscoring the transformative potential of unimolecular polypharmacology in addressing metabolic diseases and paving the way for future innovations in personalized medicine. |
| WOS关键词 | GLUCAGON-LIKE PEPTIDE-1 ; GLP-1 RECEPTOR AGONIST ; TYPE-2 DIABETES-MELLITUS ; SEMAGLUTIDE 2.4 MG ; DOUBLE-BLIND ; DUAL GIP ; EFFICACY ; SAFETY ; OBESITY ; PEOPLE |
| 资助项目 | National Natural Science Foundation of China[82273961] ; National Natural Science Foundation of China[82073904] ; National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[82273985] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[81973373] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2018ZX09735-001] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2018ZX09711002-002-005] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2023YFA1800804] ; National Science & Technology Major Project of China-Key New Drug Creation and Manufacturing Program[2021ZD0203400] ; Hainan Provincial Major Science and Technology Project[ZDKJ2021028] |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001410738300011 |
| 出版者 | ANNUAL REVIEWS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315977]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Ruijin Hosp, Translat Res Ctr Struct Biol, Sch Med, Shanghai, Peoples R China 2.Hainan Med Univ, Engn Res Ctr Trop Med Innovat & Transformat, Sch Pharm, Minist Educ, Haikou, Peoples R China 3.Univ Tokyo, Sch Sci, Dept Chem, Tokyo, Japan 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Pharmaceut Sci, Shanghai, Peoples R China 8.Res Ctr Deepsea Bioresources, Sanya, Hainan, Peoples R China 9.Fudan Univ, Sch Basic Med Sci, Dept Pharmacol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Qingtong,Li, Guanyi,Hang, Kaini,et al. Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY,2025,65:191-213. |
| APA | Zhou, Qingtong,Li, Guanyi,Hang, Kaini,Li, Jie,Yang, Dehua,&Wang, Ming-Wei.(2025).Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY,65,191-213. |
| MLA | Zhou, Qingtong,et al."Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology".ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 65(2025):191-213. |
入库方式： OAI收割
来源：上海药物研究所
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