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Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine

文献类型：期刊论文

作者Cheng, Yan7,8; Akramov, Davlat6; Yakhshilikova, Lola6; Zhu, Chengwei5; Lu, Jie7,8; Suo, Jin8; Pugazh, Santhosh8; Qin, Hongjian4,7; Abduahadi, Safomuddin7,8; Qin, Jishan7,8
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2025-01-09
卷号88期号:1页码:191-198
ISSN号0163-3864
DOI10.1021/acs.jnatprod.4c01109
英文摘要The similar structures of natural compounds and the absence of NMR data for commercial products raise the risk of misidentification. This work reports a case in which purchased samples labeled as "berbamine" from 14 suppliers are oxyacanthine (1). The NMR data of all purchased samples were consistent. The X-ray crystallography characterization of one sample revealed it to be 1. The NMR data of 1 were fully assigned for the first time. Berbamine (2) was isolated from the roots of Berberis sieboldii Miq. The NMR data of 2 were assigned, and its crystal structure was reported for the first time. The authors intend to raise awareness and support the academic/industrial community through a study of this misidentification case.
资助项目National Key Research and Development Program of China[2023YFD1800405] ; National Key Research and Development Program of China
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001393263800001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/315648]  
专题新药研究国家重点实验室
通讯作者Yang, Feipu; Aisa, Haji A.
作者单位1.Xinjiang Med Univ, Sch Pharm, Urumqi 830054, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China
3.Vigonvita Shanghai Co Ltd, Shanghai 201210, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
5.Vigonvita Life Sci Co Ltd, Suzhou 215123, Jiangsu, Peoples R China
6.Samarkand State Univ, Inst Biochem, Samarkand 140104, Uzbekistan
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Yan,Akramov, Davlat,Yakhshilikova, Lola,et al. Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine[J]. JOURNAL OF NATURAL PRODUCTS,2025,88(1):191-198.
APA Cheng, Yan.,Akramov, Davlat.,Yakhshilikova, Lola.,Zhu, Chengwei.,Lu, Jie.,...&Aisa, Haji A..(2025).Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine.JOURNAL OF NATURAL PRODUCTS,88(1),191-198.
MLA Cheng, Yan,et al."Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine".JOURNAL OF NATURAL PRODUCTS 88.1(2025):191-198.

入库方式： OAI收割

来源：上海药物研究所

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