Clerodane diterpenoids from the vine stems of Fibraurea recisa Pierre and their hepatic gluconeogenesis inhibitory activity
文献类型：期刊论文
| 作者 | Wang, Hai-Yin2,3,5; Shen, Yu4; Nie, Wei5; Tu, Wen-Chao5; Huang, Suling4 ; Wu, Xing-De1,5
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2025-04-01 |
| 卷号 | 232页码:12 |
| 关键词 | Fibraurea recisa Pi erre Menispermaceae Clerodane diterpenoids Hepatic gluconeogenesis Diabetes mellitus |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114364 |
| 英文摘要 | Fibraurea recisa Pierre is a vine plant and its vine stems are used as a traditional Chinese medicine to treat heat toxin, constipation, diarrhea, sore throat, eye inflammation, carbuncles, and skin ulcers. The alkaloid chemical composition of this plant has been extensively studied; however, investigations into non-alkaloid components remain limited. In this study, phytochemical studies of the vine stems of F . recisa were conducted, leading to the isolation and identification of twenty highly oxidized clerodane diterpenoids, including ten previously undescribed compounds, designated fibrecins A-J (1-10). The structures and absolute configurations of 1-10 were determined through comprehensive spectroscopic methods (IR, HRESIMS, 1D and 2D NMR), electronic circular dichroism data, and single-crystal X-ray diffraction. Notably, compounds 1 and 2 are rare 18-nor-clerodane diterpenoids. Excessive hepatic gluconeogenesis is an important cause of hyperglycemia and type 2 diabetes mellitus. Herein, compounds 1 , 9 , 14 , and 15 were found to exhibit moderate hepatic gluconeogenesis inhibitory activity in primary mouse hepatocytes, suggesting that these compounds might have potential effect on ameliorating the hyperglycaemia. |
| WOS关键词 | CONSTITUENTS ; FURANODITERPENOIDS ; CELLS |
| 资助项目 | National Natural Science Founda-tion of China[32370423] ; National Natural Science Founda-tion of China[22267022] ; Science Research Foundation of Department of Education of Yunnan Province[2023J0224] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001395030600001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315675]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Suling; Wu, Xing-De |
| 作者单位 | 1.Yunnan Minzu Univ, Yunnan Key Lab Chiral Funct Subst Res & Applicat, Kunming 650504, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, Minist Educ, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hai-Yin,Shen, Yu,Nie, Wei,et al. Clerodane diterpenoids from the vine stems of Fibraurea recisa Pierre and their hepatic gluconeogenesis inhibitory activity[J]. PHYTOCHEMISTRY,2025,232:12. |
| APA | Wang, Hai-Yin,Shen, Yu,Nie, Wei,Tu, Wen-Chao,Huang, Suling,&Wu, Xing-De.(2025).Clerodane diterpenoids from the vine stems of Fibraurea recisa Pierre and their hepatic gluconeogenesis inhibitory activity.PHYTOCHEMISTRY,232,12. |
| MLA | Wang, Hai-Yin,et al."Clerodane diterpenoids from the vine stems of Fibraurea recisa Pierre and their hepatic gluconeogenesis inhibitory activity".PHYTOCHEMISTRY 232(2025):12. |
入库方式： OAI收割
来源：上海药物研究所
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