Targeted characterisation of bioactive prenylated flavonoids from Ficus carica L. fruits
文献类型：期刊论文
| 作者 | Yuan, Yue1,3; Li, Zuopeng1; Aisa, Haji Akber1,2 |
| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2025-08-15 |
| 卷号 | 483页码:11 |
| 关键词 | Figs Targeted isolation Prenylated flavonoids Antioxidant Anti-inflammatory Antitubercular |
| ISSN号 | 0308-8146 |
| DOI | 10.1016/j.foodchem.2025.144201 |
| 通讯作者 | Aisa, Haji Akber(aisa@ms.xjb.ac.cn) |
| 英文摘要 | Figs (Ficus carica L.) are rich in bioactive prenylated flavonoids (PFs), which have garnered considerable attention owing to their potential health benefits. In this study, feature-based molecular networking was used to facilitate the targeted isolation of PFs components. Fifty flavonoids, including eight pairs of enantiomers, were isolated, and thirty-eight were identified as PFs. Structural characterisation of the ten novel flavonoids was achieved through comprehensive spectroscopic analysis and quantum chemical calculations. Fig extracts exhibited potent free radical scavenging capacities against DPPH and ABTS radicals. The identification of fortytwo polyphenolics using UHPLC-Q-Exactive Orbitrap MS analysis further supported these results. Several compounds showed moderate inhibitory effects against the NF-kappa B and STAT3 pathways. Structure-activity relationship analysis revealed that the prenyl type and substitution position played a pivotal role in influencing antimycobacterial activity. These findings provide novel insights into the targeted isolation, structural features, and activity profiles of PFs in figs. |
| WOS关键词 | TUBERCULOSIS ; ISOFLAVONE |
| 资助项目 | National Key Research and Development Program of China[2020YFE0205600] ; Tian-Shan Talent Program[2022TSYCLJ0064] ; Zhongshan Municipal Bureau of Science and Technology, the institute independently deployed basic research projects[E3594101] ; Youth Innovation Promotion Association of Chinese Academy of Sciences |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:001473572500001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317515]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Aisa, Haji Akber |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yue,Li, Zuopeng,Aisa, Haji Akber. Targeted characterisation of bioactive prenylated flavonoids from Ficus carica L. fruits[J]. FOOD CHEMISTRY,2025,483:11. |
| APA | Yuan, Yue,Li, Zuopeng,&Aisa, Haji Akber.(2025).Targeted characterisation of bioactive prenylated flavonoids from Ficus carica L. fruits.FOOD CHEMISTRY,483,11. |
| MLA | Yuan, Yue,et al."Targeted characterisation of bioactive prenylated flavonoids from Ficus carica L. fruits".FOOD CHEMISTRY 483(2025):11. |
入库方式： OAI收割
来源：上海药物研究所
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