Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species
文献类型：期刊论文
| 作者 | Gao, Yun6; Zhou, Xiangyu6; Yan, Mengxiao6; Wang, Zhengwei6; Zhong, Xin6; Li, Xiaochen6; Zhu, Junjie6; Kong, Yu6; Zhu, Wanrong1,2,6; Geng, Ruolin3,4 |
| 刊名 | MOLECULAR HORTICULTURE
 |
| 出版日期 | 2025-07-01 |
| 卷号 | 5期号:1页码:14 |
| 关键词 | |
| ISSN号 | 2730-9401 |
| DOI | 10.1186/s43897-025-00162-2 |
| 英文摘要 | The Corydalis genus, one of the largest within the Papaveraceae family, holds a rich diversity of medicinal resources, particularly among its tuberous species. Benzylisoquinoline alkaloids (BIAs) are primarily responsible for the medicinal properties observed in Corydalis plants. In this study, we conducted an integrated evolutionary analysis by combining whole-genome resequencing with comprehensive metabolite profiling across various Corydalis species. Guided by these initial findings, supported by local cultivation practices and an extensive literature review, we further investigated six tuberous Corydalis species: C. yanhusuo, C. decumbens, C. schanginii, C. ledebouriana, C. solida, and the newly identified C. nanchuanensis. Our results revealed conserved alkaloid profiles across these species but highlighted significant variations in key bioactive compounds. Notably, C. nanchuanensis exhibited considerably higher levels of tetrahydropalmatine compared to the commonly used medicinal species C. yanhusuo, while C. solida, originally sourced from the Netherlands, displayed elevated concentrations of corydaline, palmatine, and dehydrocorydaline. Additionally, transcriptome-metabolome correlation analyses pinpointed several critical genes involved in protopine biosynthesis, particularly emphasizing the TNMT gene family. These discoveries significantly enhance our understanding of metabolic diversity in tuberous Corydalis, providing essential insights for the exploration of novel medicinal resources and facilitating targeted genetic improvements for therapeutic use. |
| WOS关键词 | ACETYLCHOLINESTERASE ; TRANSCRIPTOME ; BERBERINE ; APOPTOSIS |
| 资助项目 | Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning |
| WOS研究方向 | Plant Sciences ; Agriculture |
| 语种 | 英语 |
| WOS记录号 | WOS:001520136000001 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318675]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ping |
| 作者单位 | 1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China 2.Fujian Agr & Forestry Univ, Haixia Inst Sci & Technol, Synthet Biol Ctr, Sch Future Technol, Fuzhou 350002, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Mol Plant Sci, State Key Lab Plant Mol Genet, Shanghai 200032, Peoples R China 6.Chinese Acad Sci, Shanghai Key Lab Plant Funct Genom & Resources, Shanghai Chenshan Bot Garden, Ctr Excellence Mol Plant Sci,Chenshan Sci Res Ctr, Shanghai 201602, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yun,Zhou, Xiangyu,Yan, Mengxiao,et al. Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species[J]. MOLECULAR HORTICULTURE,2025,5(1):14. |
| APA | Gao, Yun.,Zhou, Xiangyu.,Yan, Mengxiao.,Wang, Zhengwei.,Zhong, Xin.,...&Xu, Ping.(2025).Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species.MOLECULAR HORTICULTURE,5(1),14. |
| MLA | Gao, Yun,et al."Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species".MOLECULAR HORTICULTURE 5.1(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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