Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities
文献类型：期刊论文
| 作者 | Chen, Demei2,3; Yuan, Yue1; Li, Zuopeng1; Zhao, Haiqing1; Zang, Deng1; Liu, Changhua2; Aisa, Haji Akber1,2,3 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2025-07-21 |
| 页码 | 9 |
| 关键词 | antimicrobial benzofurans coumarins Ficus carica L. melanogenic |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202500961 |
| 通讯作者 | Aisa, Haji Akber(haji@ms.xjb.ac.cn) |
| 英文摘要 | Although fig leaves are widely used for dermatological treatment in traditional medicine, research on the bioactivity of their components is limited. In this study, an ultraviolet-guided approach was employed to isolate 2 novel benzofurans (1-2), 12 known benzofurans (3-14), and 13 known coumarins (15-26a/26b). Compounds 4-10, 13-14, 17, 20, 24, and 26a/26b were detected in fig leaves for the first time. Their structures were elucidated through comprehensive spectral analysis, 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization, and literature comparison. The absolute configurations of compounds 18, 22-24, and 26a/26b were determined using the Snatzke method and electronic circular dichroism analysis. Compounds 4, 6, and 18 exhibited antimicrobial activity in vitro against Candida albicans and Staphylococcus aureus with MIC/MBC values ranging from 250 to 2000 mu M. Compound 16 exhibited significant melanogenic activity, yielding a relative melanin content of 147.7% (p < 0.0001). Compounds 15 and 22 showed moderate melanogenic activity, resulting in relative melanin contents of 118.1% and 119.9% (p < 0.05), respectively. |
| 资助项目 | Zhongshan Municipal Bureau of Science and Technology ; National Key R&D Program of China[2020YFE0205600] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Xinjiang Science and Technology Key Research and Development[2024B02023-2] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001532808600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318861]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Aisa, Haji Akber |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 3.Guangzhou Univ Chinese Med, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Demei,Yuan, Yue,Li, Zuopeng,et al. Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities[J]. CHEMISTRY & BIODIVERSITY,2025:9. |
| APA | Chen, Demei.,Yuan, Yue.,Li, Zuopeng.,Zhao, Haiqing.,Zang, Deng.,...&Aisa, Haji Akber.(2025).Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities.CHEMISTRY & BIODIVERSITY,9. |
| MLA | Chen, Demei,et al."Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities".CHEMISTRY & BIODIVERSITY (2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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