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Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer

文献类型：期刊论文

作者Wang, Xiaoshuang6; Wu, Zhongen5; Zhou, Yan4; Yang, Dehua4; Zhou, Qingtong3; Zhu, Di2,3,5; Wang, Ming-Wei1,3; Wang, Lu6
刊名SCIENTIFIC REPORTS
出版日期2025-07-01
卷号15期号:1页码:13
关键词NK-T interaction Liver metastasis Single-cell transcriptomics
ISSN号2045-2322
DOI10.1038/s41598-025-06241-0
通讯作者Zhu, Di(zhudifudan@163.com) ; Wang, Ming-Wei(mwwang@simm.ac.cn) ; Wang, Lu(cms024mm@163.com)
英文摘要Natural killer (NK) cells and T cells play crucial roles in liver metastatic cancer, particularly through their cytotoxic effects on tumor cells. Although existing evidence suggests a functional network of mutual regulation between NK and T cells, the nature of their interaction and its role in liver metastasis remain elusive. In this study, we analyzed single-cell transcriptomics of liver metastases and adjacent tissues from nasopharyngeal carcinoma (NPC), thyroid carcinoma (THCA), breast cancer (BC), colorectal cancer (CRC) and cervical cancer (CESC) to uncover the NK-T cell interaction network and its functional implications. In adjacent tissues, we observed increased infiltration of CD8+ NKT-like cells, gamma delta T cells, and NK cells. The interaction between CD8+ NKT-like cells, CD8+ T cells, gamma delta T cells, and NK cells were enhanced, with stronger signals associated with T and NK cell functions. Notably, CD8+ NKT-like cells, CD8+ T cells, and gamma delta T cells exhibited an increased capacity to activate NK cells. These T cell subsets promoted NK cell anti-tumor activity via CD48-CD244 and TNF-TNFR signaling pathways, which in turn activated the ERK, JNK, and MAPK cascades. Our findings provide valuable insights into the NK-T cell interaction network in liver metastatic cancer, highlighting its potential as a therapeutic target.
WOS关键词GRANULE POLARIZATION ; GAMMA PRODUCTION ; ACTIVATION ; RESPONSES
资助项目Science and Technology Commission of Shanghai Municipality
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001523006000021
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/321045]  
专题中国科学院上海药物研究所
通讯作者Zhu, Di; Wang, Ming-Wei; Wang, Lu
作者单位1.Res Ctr Deepsea Bioresources, Sanya 572025, Hainan, Peoples R China
2.Fudan Univ, Minhang Hosp, Shanghai Med Coll, Shanghai 201100, Peoples R China
3.Fudan Univ, Sch Basic Med Sci, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
5.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
6.Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaoshuang,Wu, Zhongen,Zhou, Yan,et al. Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer[J]. SCIENTIFIC REPORTS,2025,15(1):13.
APA Wang, Xiaoshuang.,Wu, Zhongen.,Zhou, Yan.,Yang, Dehua.,Zhou, Qingtong.,...&Wang, Lu.(2025).Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer.SCIENTIFIC REPORTS,15(1),13.
MLA Wang, Xiaoshuang,et al."Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer".SCIENTIFIC REPORTS 15.1(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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