Swinging the SWI/SNF complexes for cancer therapy
文献类型：期刊论文
| 作者 | Jing, Hongyan1,2; Zhang, Xi2; Meng, Linghua1,2 |
| 刊名 | TRENDS IN PHARMACOLOGICAL SCIENCES
 |
| 出版日期 | 2025-09-01 |
| 卷号 | 46期号:9页码:907-921 |
| ISSN号 | 0165-6147 |
| DOI | 10.1016/j.tips.2025.07.008 |
| 通讯作者 | Meng, Linghua(lhmeng@simm.ac.cn) |
| 英文摘要 | SWI/SNF chromatin remodeling complexes are essential epigenetic regulators that control chromatin accessibility and transcriptional programs. Alterations in SWI/SNF components are common across a wide spectrum of human cancers, driving tumorigenesis through diverse mechanisms. Increasing insights into the oncogenic roles of aberrant SWI/SNF complexes have spurred the development of novel therapeutic strategies. In this review, we integrate large-scale cancer genomic data towards understanding tumorigenesis driven by alterations in subunits of SWI/SNF complexes. We also evaluate strategies exploiting vulnerabilities in SWI/SNF-mutant cancers, including direct targeting of residual complex components and unique dependencies in critical cellular processes. Among them, one drug has been approved, and several others are in clinical trials. |
| WOS关键词 | CHROMATIN REMODELING COMPLEXES ; SMALL-CELL CARCINOMA ; SYNTHETIC LETHALITY ; DEFICIENCY ; SMARCA4 ; TUMOR ; OVARY ; BRD9 ; PRC2 ; SNF5 |
| 资助项目 | National Key Research and Development Program of China[2024YFA1210200] ; National Natural Science Foundation of China[82173832] ; State Key Laboratory of Chemical Biology ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1060000] ; State Key Laboratory of Drug Research[SKLDR-2024-KF-01] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001568821000011 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321477]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Meng, Linghua |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Chem Biol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Hongyan,Zhang, Xi,Meng, Linghua. Swinging the SWI/SNF complexes for cancer therapy[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2025,46(9):907-921. |
| APA | Jing, Hongyan,Zhang, Xi,&Meng, Linghua.(2025).Swinging the SWI/SNF complexes for cancer therapy.TRENDS IN PHARMACOLOGICAL SCIENCES,46(9),907-921. |
| MLA | Jing, Hongyan,et al."Swinging the SWI/SNF complexes for cancer therapy".TRENDS IN PHARMACOLOGICAL SCIENCES 46.9(2025):907-921. |
入库方式： OAI收割
来源：上海药物研究所
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