中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [36]
深圳先进技术研究院 [1]
采集方式
OAI收割 [37]
内容类型
期刊论文 [37]
发表日期
2023 [3]
2022 [3]
2021 [1]
2020 [1]
2019 [8]
2018 [1]
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浏览/检索结果:
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Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15
作者:
Wen, Xin
;
Zhang, Minmin
;
Duan, Zhiqiang
;
Suo, Yanrui
;
Lu, Weiwei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/10/17
Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Wu, Feifei
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Hematopoietic progenitor kinase 1 (HPK1)
Cancer immunotherapy
Inhibitor
T cell
Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 153
作者:
Zhang, Xu
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3K alpha inhibitors in oesophageal squamous cell carcinoma
期刊论文
OAI收割
CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 卷号: 12, 期号: 5, 页码: 17
作者:
Xing, Hui
;
Gao, Mengshi
;
Wang, Yuxiang
;
Zhang, Xu
;
Shi, Jiajie
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/08/16
CDKNIA
cell cycle
CRISPR-SAM
CYH33
ESCC
EZH2
PI3K alpha inhibitor
resistance
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 3, 页码: 1054-1067
作者:
Zhang, Xu
;
Wang, Yuxiang
;
Meng, Linghua
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/15
Esophageal cancer
Esophageal squamous cell carcinoma
Esophageal adenocarcinoma
Next-generation sequencing
Genomic alteration
Somatic mutation
Copy number variation
Molecularly targeted therapy
SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 209
作者:
Zhang Xi
;
Duan Yuting
;
Wang Yi
;
Zhao Xingdong
;
Sun Yiming
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/05/22
PI3K6
PI3K/AKT/mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
PI3K alpha inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 3
作者:
Xie, Qin
;
Chi, Shuaishuai
;
Fang, Yanfen
;
Sun, Yiming
;
Meng, Linghua
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2021/05/24
N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.
期刊论文
OAI收割
CANCER IMMUNOLOGY RESEARCH, 2020, 卷号: 8, 期号: 3, 页码: 51-51
作者:
Chen, Shulun
;
Guo, Wei
;
Sun, Pu
;
Meng, Linghua
;
Zhang, Ao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas
期刊论文
OAI收割
MOLECULAR CANCER THERAPEUTICS, 2019, 卷号: 18, 期号: 12, 页码: 2
作者:
Wang, Yuxiang
;
Zhang, Xu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives