Cassane diterpenoids with hepatic gluconeogenesis inhibitory activity from the seeds of Caesalpinia decapetala (Roth) Alston
文献类型：期刊论文
| 作者 | Wang, De-Sheng1,2; Shen, Yu3; Ding, Lin-Fen2; Yan, Run-Cheng1; Hu, Ming1; Tu, Wen-Chao1; Song, Liu-Dong2; Huang, Suling3; Wu, Xing-De1 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 240页码:11 |
| 关键词 | Leguminosae Cassane diterpenoids Hepatic gluconeogenesis Diabetes mellitus |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114628 |
| 英文摘要 | A chemical investigation of the seeds of Caesalpinia decapetala (Roth) Alston led to the isolation of fifteen cassane diterpenoids, including ten previously undescribed compounds (1-10) and five known analogues (11-15). The structures of 1-10 were determined using 1H, 13C, and 2D NMR, HRESIMS, and IR data. Their absolute configurations were confirmed by comparing experimental electronic circular dichroism data with calculated values, coupled with single-crystal X-ray diffraction analysis. Structurally, compounds 1 and 2 are rare cassane diterpenoids featuring a ketone carbonyl group at C-3. Excessive hepatic gluconeogenesis plays an important role in the occurrence and development of type 2 diabetes mellitus. In the present study, compounds 1, 3, 4, 6, 11, and 12 exhibited potent inhibitory effects on gluconeogenesis at a concentration of 20 mu M in primary mouse hepatocytes, with inhibitory capacities of 68.2 f 6.8 %, 78.4 f 3.5 %, 53.8 f 6.1 %, 94.8 f 5.5 %, 85.1 f 4.1 %, and 106.9 f 2.9 %, respectively. Further studies indicated that these compounds inhibited gluconeogenesis in a dose-dependent manner across a concentration range from 1 to 50 mu M. Notably, compounds 6 and 12 exhibited potent inhibitory effects on gluconeogenesis at a concentration of 2 mu M, comparable to the effects of 500 mu M metformin, suggesting their potential for ameliorating hyperglycemia. |
| WOS关键词 | GLUCOSE-METABOLISM ; STRUCTURE REVISION |
| 资助项目 | National Natural Science Foundation of China[81773611] ; National Natural Science Foundation of China[82073905] ; National Natural Science Foundation of China[32370423] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001541559100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321150]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Huang, Suling; Wu, Xing-De |
| 作者单位 | 1.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, Minist Educ, Kunming 650504, Yunnan, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, De-Sheng,Shen, Yu,Ding, Lin-Fen,et al. Cassane diterpenoids with hepatic gluconeogenesis inhibitory activity from the seeds of Caesalpinia decapetala (Roth) Alston[J]. PHYTOCHEMISTRY,2025,240:11. |
| APA | Wang, De-Sheng.,Shen, Yu.,Ding, Lin-Fen.,Yan, Run-Cheng.,Hu, Ming.,...&Wu, Xing-De.(2025).Cassane diterpenoids with hepatic gluconeogenesis inhibitory activity from the seeds of Caesalpinia decapetala (Roth) Alston.PHYTOCHEMISTRY,240,11. |
| MLA | Wang, De-Sheng,et al."Cassane diterpenoids with hepatic gluconeogenesis inhibitory activity from the seeds of Caesalpinia decapetala (Roth) Alston".PHYTOCHEMISTRY 240(2025):11. |
入库方式： OAI收割
来源：上海药物研究所
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