Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats
文献类型：期刊论文
| 作者 | Zhao, Yuqing1,5,6; Yuan, Yali1; Yan, Shu1; Tang, Chongzhuang5; Gan, Yong2,3,4; Guo, Shiyan3,4; Diao, Xingxing1,5,6 |
| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 39期号:12页码:10 |
| 关键词 | metabolism phloretin phlorizin trilobatin UHPLC-UV-HRMS |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.70265 |
| 英文摘要 | The total flavonoid extract of Lithocarpus litseifolius (Hance) Chun (TFLLC), a medicinal and edible plant of the Fagaceae family, has been developed as a preclinical drug candidate in China due to its hypoglycemic effect. The metabolism of TFLLC is closely associated with both its pharmacological activity and potential toxicity. This study investigated the in vitro and in vivo metabolism of TFLLC, which mainly comprises phlorizin and trilobatin. Ultrahigh-performance liquid chromatography coupled with UV spectrometry and high-resolution mass spectrometry (UHPLC-UV-HRMS) was used to detect and characterize TFLLC metabolites in rats following oral administration at 50 mg/kg. TFLLC underwent extensive metabolic transformation, and 13 metabolites were identified. The major drug-related substances included phloretin-derived from glycosidic cleavage of phlorizin and trilobatin-and its conjugated derivatives, such as glucuronidated metabolite M450, sulfated metabolite M354, and dual-conjugated metabolite M530. These metabolites were primarily excreted in bile and urine. Intestinal incubation studies confirmed that phloretin formation could occur in the gut. These findings provide a pharmacokinetic basis to support the pharmacodynamic interpretation and future drug development of TFLLC. |
| WOS关键词 | POLYSTACHYUS REHD. ; IN-VIVO ; ABSORPTION ; PHLORETIN ; MECHANISM |
| 资助项目 | Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[82373938] ; National Natural Science Foundation of China[82204585] ; Key Technologies R&D Program of Guangdong Province[2023B1111030004] ; National Key R&D Program of China[2022YFF1202600] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001619908100016 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/322160]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Guo, Shiyan; Diao, Xingxing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Ctr Drug Metab & Pharmacokinet, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai, Peoples R China 5.XenoFinder Co Ltd, Suzhou, Peoples R China 6.Tianjin Univ Tradit Chinese Med, Acad Tradit Chinese Med, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yuqing,Yuan, Yali,Yan, Shu,et al. Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats[J]. BIOMEDICAL CHROMATOGRAPHY,2025,39(12):10. |
| APA | Zhao, Yuqing.,Yuan, Yali.,Yan, Shu.,Tang, Chongzhuang.,Gan, Yong.,...&Diao, Xingxing.(2025).Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats.BIOMEDICAL CHROMATOGRAPHY,39(12),10. |
| MLA | Zhao, Yuqing,et al."Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats".BIOMEDICAL CHROMATOGRAPHY 39.12(2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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