Development of microfluidic-based telemedicine for diabetes care and screening
文献类型：期刊论文
| 作者 | Yao P(姚萍) ; Tong ZH(童兆宏); Zhan ZK(詹志坤); Hua JN(化建宁); Dong ZL(董再励)
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| 刊名 | TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
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| 出版日期 | 2013 |
| 卷号 | 35期号:7页码:893-900 |
| 关键词 | Chemiluminescence immunoassay diabetes screening insulin detection microfluidic system telemedicine |
| ISSN号 | 0142-3312 |
| 产权排序 | 1 |
| 通讯作者 | 姚萍 |
| 中文摘要 | This paper describes a microfluidic-based telemedicine system for insulin detection and conveying the results digitally to physicians located off-site through the Internet. The communication infrastructure is designed to transfer the digital information from the assay site to established healthcare facilities where trained medical professionals can directly assist the detection process and provide diagnosis. The insulin detection device of the telemedicine system is an integrated polydimethysiloxane (PDMS) microfluidic device consisting of two pneumatic micropumps and one micromixer. The insulin detection protocol is based on microbeads-based double-antibody sandwich immunoassay coupled with luminal-hydrogen peroxide (H2O2) chemiluminescence. A photometer detects the peak value of the luminous intensity, which indicates the insulin concentration of the patient plasma sample tested. The calibration curves of the insulin detection protocol have been quantified. The insulin detection limit of the microfluidic system is 4x10(-10)mol/l, which meets the common requirement of the current clinical studies of diabetes. Multiple immune indicators of diabetes can potentially be detected synchronously by the microfluidic system, thus providing physicians with integrative results necessary for accurate diagnosis via the Internet. The combination of microfluidic devices and telemedicine strategy offers new opportunities for diabetes care and screening, especially in rural areas where patients must travel long distances to physicians for healthcare information that might be obtained more cost effectively by local, less-trained personnel. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Automation & Control Systems ; Instruments & Instrumentation |
| 研究领域[WOS] | Automation & Control Systems ; Instruments & Instrumentation |
| 关键词[WOS] | INSULIN ; MANAGEMENT ; INJECTION ; SYSTEMS ; TIME |
| 收录类别 | SCI ; EI |
| 资助信息 | This project is funded by the State Key Laboratory of Robotics (Grant No. RLZ200808; RLO200812) and the National High Technology Research and Development Program of China (Grant No. 2009AA04Z313). Support is also provided by the CAS/SAFEA International Partnership Program for Creative Research Teams. |
| 语种 | 英语 |
| WOS记录号 | WOS:000326173800005 |
| 公开日期 | 2013-12-27 |
| 源URL | [http://ir.sia.cn/handle/173321/14071]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 推荐引用方式 GB/T 7714 | Yao P,Tong ZH,Zhan ZK,et al. Development of microfluidic-based telemedicine for diabetes care and screening[J]. TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,2013,35(7):893-900. |
| APA | Yao P,Tong ZH,Zhan ZK,Hua JN,&Dong ZL.(2013).Development of microfluidic-based telemedicine for diabetes care and screening.TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL,35(7),893-900. |
| MLA | Yao P,et al."Development of microfluidic-based telemedicine for diabetes care and screening".TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL 35.7(2013):893-900. |
入库方式： OAI收割
来源：沈阳自动化研究所
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