Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
文献类型：期刊论文
| 作者 | Tuerxuntayi, Adila; Liu, Yong-qiang ; Tulake, Ablajan; Kabas, Maidina; Eblimit, Aiden; Aisa, Haji Akber
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| 刊名 | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:5 |
| 关键词 | KZE Melanogenesis B16 melanoma cells TYR MITF |
| ISSN号 | 1472-6882 |
| 通讯作者 | Aisa, HA |
| 中文摘要 | Background: Kaliziri extract (KZE) is a traditional Uyghur medicine (TUM), used by traditional hospitals in China as an injection for treatment of vitiligo for more than 30 years. Clinical application has shown that this medicine has obvious therapeutic effects. However, its phytochemical analysis and mechanism have not been examined. Methods: KZE was extracted from seeds of Kaliziri [Vernonia anthelmintica (L.) Willd.] in ethanol-water (80: 20, v/v), its components were identified by LC-MS/MS, and the signaling pathway of melanin synthesis in KZE treated murine B16 melanoma cells was examined by western blotting. Results: Liquid chromatography-mass spectrometry analysis confirmed that the main components of KZE are flavonoids. KZE increased the tyrosinase activity and melanin content in a dose-dependent manner at concentrations of 5-40 mu g/ml, and treatment with 20 mu g/ml of KZE enhanced the expression of tyrosinase in B16 cells in a time-dependent manner. Conclusions: KZE induced melanogenesis by increasing the expression of TYR, TRP-1, TRP-2 and MITF in B16 cells. |
| 收录类别 | SCI |
| 资助信息 | International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) |
| 公开日期 | 2014-11-11 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/3782]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA;Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,et al. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14(5). |
| APA | Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,Kabas, Maidina,Eblimit, Aiden,&Aisa, Haji Akber.(2014).Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14(5). |
| MLA | Tuerxuntayi, Adila,et al."Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14.5(2014). |
入库方式： OAI收割
来源：新疆理化技术研究所
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