Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension
文献类型：期刊论文
| 作者 | Bakri, Mahinur; Yi Yang; Chen Ling-Dan; Aisa, Haji Akber ; Wang Mong-Heng
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:4页码:266-272 |
| 关键词 | Nitraria sibirica Alkaloids Blood pressure High salt diet Hypertension Albuminuria |
| ISSN号 | 2095-6975 |
| 中文摘要 | In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA(1 mg.kg(-1.)d(-1), i.p.)). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant ptotein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers. |
| 收录类别 | SCI |
| 资助信息 | West Light Foundation of the Chinese Academy of Science；ABA DODI grant from Georgia Health Sciences University |
| 公开日期 | 2014-11-11 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/3793]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Georgia Regents Univ, Dept Physiol, Augusta, GA 30912 USA |
| 推荐引用方式 GB/T 7714 | Bakri, Mahinur,Yi Yang,Chen Ling-Dan,et al. Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(4):266-272. |
| APA | Bakri, Mahinur,Yi Yang,Chen Ling-Dan,Aisa, Haji Akber,&Wang Mong-Heng.(2014).Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension.CHINESE JOURNAL OF NATURAL MEDICINES,12(4),266-272. |
| MLA | Bakri, Mahinur,et al."Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension".CHINESE JOURNAL OF NATURAL MEDICINES 12.4(2014):266-272. |
入库方式： OAI收割
来源：新疆理化技术研究所
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