Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents
文献类型：期刊论文
| 作者 | Lu, Dongli; Liu, Yongqiang ; Aisa, Haji Akber
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014 |
| 卷号 | 92期号:1页码:244-251 |
| 关键词 | Euphorbia sororia Uyghur medicine Jatrophane diterpenoid esters Multidrug resistance reversal activity |
| ISSN号 | 0367-326X |
| 通讯作者 | Aisa, HA |
| 中文摘要 | Six (1-6) new jatrophane diterpenoid esters together with four known compounds (7-10) were isolated from the acetone extract of fructus Euphorbia sororia. Their structures were elucidated by the spectral technology, including the 2D NMR experiments (HMQC, HMBC and NOESY). The absolute configuration of compound 1 and compound 7 were first confirmed by X-ray crystallographic analysis. Compounds 1-7 were assayed for their antiproliferative activity in human cancer cell lines: human mammary adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549). All the compounds were inactive for the cell lines. The multidrug-resistance reversal activity was also tested on KBv200 cells and compound 2 displayed strong multidrug resistance reversal activity, outperforming verapamil at 10 mu M. |
| 收录类别 | SCI |
| 资助信息 | International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China |
| 公开日期 | 2014-11-11 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/3838]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Dongli,Liu, Yongqiang,Aisa, Haji Akber. Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents[J]. FITOTERAPIA,2014,92(1):244-251. |
| APA | Lu, Dongli,Liu, Yongqiang,&Aisa, Haji Akber.(2014).Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents.FITOTERAPIA,92(1),244-251. |
| MLA | Lu, Dongli,et al."Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents".FITOTERAPIA 92.1(2014):244-251. |
入库方式： OAI收割
来源：新疆理化技术研究所
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