Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)
文献类型：期刊论文
| 作者 | Lu, XM; Jiang, L; Mao, XA; Ye, CH; Lu, JF; Cui, JR |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2005-06-01 |
| 卷号 | 23期号:6页码:781-785 |
| 关键词 | cis-dioxo-molybdenum(V) cis-dioxo-molybdo(V)tungsten(VI) cis-dioxo-tungsten(VI) catechol adenosine triphosphate DNA cleavage antitumor |
| 英文摘要 | (NH3CH2CH2NH2)(3)[MO(V)O-2(O2C6H4) (1), (NH3CH2CH2NH2)(2.5)[MO(V)(0.5)W(V)(0.5)O-2(O2C6H4)(2)] (2) and (NH3CH2CH2NH2)(2)[W(VI)O-2(O2C6H4)(2)] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox stale of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from)V(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(V) to M(VI) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S-180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CRYSTAL-STRUCTURE ; TETRATHIOMOLYBDATE ; CHEMISTRY ; AGENTS ; EPR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000229408100025 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4481]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 3.Perkin Univ, Sch Pharmaceut Sci, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, XM,Jiang, L,Mao, XA,et al. Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)[J]. CHINESE JOURNAL OF CHEMISTRY,2005,23(6):781-785. |
| APA | Lu, XM,Jiang, L,Mao, XA,Ye, CH,Lu, JF,&Cui, JR.(2005).Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-).CHINESE JOURNAL OF CHEMISTRY,23(6),781-785. |
| MLA | Lu, XM,et al."Interactions with ATP, DNA cleavage and anti-tumor activities of complexes with anions [Mo(V)O-2(O2C6H4)(2)](3-),[Mo(V)(0.5)W(VI)(0.5)O-2(O2C6H4)(2)](2.5-) and [W(VI)O-2(O2C6H4)(2)](2-)".CHINESE JOURNAL OF CHEMISTRY 23.6(2005):781-785. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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