Finite element simulation of stress relaxation process in living cells
文献类型：会议论文
| 作者 | Wei FN(魏发南) ; Zhou PL(周培林); Li GY(李广勇); Liu LQ(刘连庆)
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| 出版日期 | 2015 |
| 会议名称 | 10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015 |
| 会议日期 | April 7, 2015 - April 11, 2015 |
| 会议地点 | Xi'an, China |
| 关键词 | Cell mechanics Finite element simulation Viscoelastic |
| 页码 | 67-71 |
| 中文摘要 | In this manuscript, we investigated the fundamental mechanism of stress relaxation phenomenon by employing finite element simulation. Through finite element simulations, the evolution of stress distribution, deformation field and the interaction force was wholly recorded during both the loading and stress relaxation stages. With the developed simulation model, the sensitivity of force-time curves on cell height and substrate stiffness was thoroughly studied by changing the thickness of cell and Young's modulus of the substrate. The simulation results indicated that the variation of cell height leads to the significant change of F-t curve's magnitude but tiny deviation of the curve's shape. And the influence originates from the substrate can be totally eliminated with relatively hard substrate. Finally, using the viscoelastic parameters extracted from actual stress relaxation experiment, the dynamic mechanical behavior of L929 cells is simulated and investigated. A comparison between the experimental and simulation F-t curves demonstrated the effectiveness of the proposed finite element simulation approach. |
| 收录类别 | EI ; CPCI（ISTP） |
| 产权排序 | 1 |
| 会议主办者 | Institute of Electrical and Electronics Engineers Inc. |
| 会议录 | 2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
 |
| 会议录出版者 | IEEE |
| 会议录出版地 | Piscataway, NJ, USA |
| 语种 | 英语 |
| ISBN号 | 978-1-4673-6695-3 |
| WOS记录号 | WOS:000380505700017 |
| 源URL | [http://ir.sia.cn/handle/173321/16899]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 推荐引用方式 GB/T 7714 | Wei FN,Zhou PL,Li GY,et al. Finite element simulation of stress relaxation process in living cells[C]. 见:10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015. Xi'an, China. April 7, 2015 - April 11, 2015. |
入库方式： OAI收割
来源：沈阳自动化研究所
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