Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies
文献类型：期刊论文
| 作者 | Xie, Lijuan1; Qian, Xuhong1,2; Cui, Jingnan1; Xiao, Yi1; Wang, Kewei1; Wu, Peichun3; Cong, Liying1 |
| 刊名 | bioorganic & medicinal chemistry
 |
| 出版日期 | 2008-09-15 |
| 卷号 | 16期号:18页码:8713-8718 |
| 关键词 | DNA-intercalator antitumor furoquinolinone N-substituted furoquinolinone |
| 英文摘要 | a series of novel n-substituted angular furoquinolinone derivatives were synthesized and evaluated for their antitumor activities against qgy, k562, hela, p388, and a549 cell lines in vitro. the derivatives bearing basic amino side chain showed an improved antitumor activity. compound 5h n-(2-dimethylaminoethyl)-2-(4,8,9-trimethyl-2-oxo-2h-furo[2,3-h]quinolin-1-yl)-acetamide exhibited the highest activities against p388 and a549 cell lines, which are evidenced by the ic(50) values that are four to five fold lower than that for unsubstituted parent compound. dna-binding experiments suggested that these derivatives bind to dna through intercalation. (c) 2008 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemistry & molecular biology ; chemistry, medicinal ; chemistry, organic |
| 研究领域[WOS] | biochemistry & molecular biology ; pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | beta-carboline derivatives ; biological evaluation ; cancer-therapy ; side-chains ; mode ; intercalators ; molecules ; mechanism ; efficient ; psoralen |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259173400045 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141034]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Lijuan,Qian, Xuhong,Cui, Jingnan,et al. Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies[J]. bioorganic & medicinal chemistry,2008,16(18):8713-8718. |
| APA | Xie, Lijuan.,Qian, Xuhong.,Cui, Jingnan.,Xiao, Yi.,Wang, Kewei.,...&Cong, Liying.(2008).Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies.bioorganic & medicinal chemistry,16(18),8713-8718. |
| MLA | Xie, Lijuan,et al."Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies".bioorganic & medicinal chemistry 16.18(2008):8713-8718. |
入库方式： OAI收割
来源：大连化学物理研究所
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