Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry
文献类型：期刊论文
| 作者 | Wang, Hailiang1; Gao, Tingting2,3; Du, Yuzhi2,3; Yang, Hongxia2,3; Wei, Lixin2,3; Bi, Hongtao2,4; Ni, Weihua5 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2015-10-20 |
| 卷号 | 131页码:288-296 |
| 关键词 | Homogalacturonan Hippophae rhamnoides L. Antitumor activity Immunostimulating activity |
| 中文摘要 | our previous study isolated an anti-fatigue polysaccharide (hrwp) from the hippophae rhamnoides berry. in this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide hrwp-a was isolated from hrwp. structural analysis determined that hrwp-a was a polysaccharide with repeating units of (1 -> 4)-beta-d-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. an antitumor activity assay showed that hrwp-a could significantly inhibit the lewis lung carcinoma (llc) growth in tumor-bearing mice. further experiments suggested that the antitumor effect of hrwp-a might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting nk cell activity and ctl cytotoxicity in tumor-bearing mice. to our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the h. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (c) 2015 elsevier ltd. all rights reserved. |
| 英文摘要 | our previous study isolated an anti-fatigue polysaccharide (hrwp) from the hippophae rhamnoides berry. in this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide hrwp-a was isolated from hrwp. structural analysis determined that hrwp-a was a polysaccharide with repeating units of (1 -> 4)-beta-d-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. an antitumor activity assay showed that hrwp-a could significantly inhibit the lewis lung carcinoma (llc) growth in tumor-bearing mice. further experiments suggested that the antitumor effect of hrwp-a might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting nk cell activity and ctl cytotoxicity in tumor-bearing mice. to our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the h. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (c) 2015 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | water-soluble polysaccharide ; tumor-bearing mice ; structural-characterization ; pectic polysaccharides ; biological-activities ; fruits ; roots ; acids ; tea |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361183600035 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/5494]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Jilin Univ, Hosp 2, Dept Neurosurg, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Tibetan Med Res, Xining 810008, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China 5.Jilin Univ, Dept Immunol, Coll Basic Med Sci, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hailiang,Gao, Tingting,Du, Yuzhi,et al. Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry[J]. carbohydrate polymers,2015,131:288-296. |
| APA | Wang, Hailiang.,Gao, Tingting.,Du, Yuzhi.,Yang, Hongxia.,Wei, Lixin.,...&Ni, Weihua.(2015).Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry.carbohydrate polymers,131,288-296. |
| MLA | Wang, Hailiang,et al."Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry".carbohydrate polymers 131(2015):288-296. |
入库方式： OAI收割
来源：西北高原生物研究所
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