中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [37]
采集方式
OAI收割 [37]
内容类型
期刊论文 [37]
发表日期
2021 [37]
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发表日期:2021
专题:上海药物研究所
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A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
OAI收割
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
Requirments for primary human hepatocyte
期刊论文
OAI收割
CELL PROLIFERATION, 2021, 页码: 6
作者:
Peng, Zhaoliang
;
Wu, Jiaying
;
Hu, Shijun
;
Ma, Aijin
;
Wang, Lei
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
primary human hepatocyte
quality control
standard
AutoGGN: A gene graph network AutoML tool for multi-omics research
期刊论文
OAI收割
Artificial Intelligence in the Life Sciences, 2021, 卷号: 1, 页码: 100019
作者:
Zhang, Lei
;
Shen, Wen
;
Li, Ping
;
Xu, Chi
;
Liu, Denghui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/14
Multi-omics Data
Molecular Interaction Network
Graph Convolution Network
Deep Learning
Single-Cell Stage Classification
Cancer Type Classification
Cancer Subtyping
Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5
作者:
Wang, Leiming
;
Li, Xin
;
Cui, Hong
;
Lei, Xinsheng
;
Liu, Hongchun
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/12/01
Marine nature products
Plocabulin
PM060184
Synthesis
Antiproliferation
Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora
期刊论文
OAI收割
PLANTA MEDICA, 2021, 页码: 7
作者:
Lei, Chun
;
Li, Ya-Nan
;
Li, Jia-Nan
;
Zhou, Yu-Bo
;
Cui, Ming-Jun
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/12/16
Trewia nudiflora
Euphorbiaceae
maytansinoids
cytotoxicity
tubulin polymerization
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/04
Two New Oleanane-Triterpenoid Saponins from Clinopodium gracile
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2021, 页码: 8
作者:
Zhao, Ting
;
Liu, Yi-Nan
;
Sun, Xin-Yu
;
Li, Jing-Ya
;
Lei, Chun
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/12/01
Clinopodium gracile
Lamiaceae
triterpenoid saponins
oleanane
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing
期刊论文
OAI收割
CELL METABOLISM, 2021, 卷号: 33, 期号: 10, 页码: 2004-+
作者:
Li, Yufeng
;
Xu, Junyu
;
Lu, Yuting
;
Bian, Hua
;
Yang, Lin
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2022/01/18
Development of peptide epoxyketones as selective immunoproteasome inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 221, 页码: 113556
作者:
Li, Xuemei
;
Hong, Duidui
;
Zhang, Mengmeng
;
Xu, Lei
;
Zhou, Yubo
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/21
Epoxyketones
Immunoproteasome inhibitor
Selectivity
Multiple myeloma
Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
期刊论文
OAI收割
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:
Xu, Jianghong
;
Hu, Yuanyuan
;
Liu, Xiaoqi
;
Gao, Anhui
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/12/01
IDH1-R132H inhibitors
synthesis
biological activity
docking
3-(indol-3-yl)-4-(pyrazolo-[3
4-c]pyridazin-3-yl)-maleimides