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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [205]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors
期刊论文
OAI收割
ADVANCED DRUG DELIVERY REVIEWS, 2025, 卷号: 224, 页码: 27
作者:
Zhang, Ping
;
Pan, Jiaxing
;
Lin, Shutong
;
Peng, Bo
;
An, Caiyan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Pancreatic cancer
Cancer immune cycle
Immune resistance
Drug delivery systems
Stimuli-responsive
The Flat Tail in the Burst Energy Distribution of FRB 20240114A
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 8
作者:
Huang YX(黄玉祥)
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/07/14
stars: general
stars: magnetars
radio continuum: stars
stars: neutron
Opportunities to mitigate process-related greenhouse gas emissions in global trade networks
期刊论文
OAI收割
SUSTAINABLE PRODUCTION AND CONSUMPTION, 2025, 卷号: 57, 页码: 375-387
作者:
Xu, Simin
;
Peng, Yunan
;
Yan, Kejia
;
Han, Mengyao
;
Zhang, Bo
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/07/18
Industrial process
Greenhouse gas emission
Complex trade network
Global supply chain
Tunable Rhodamine Mechanophores: Designing a Mechanochromic Platform for Stress Mapping in Polymeric Materials
期刊论文
OAI收割
MACROMOLECULES, 2025, 卷号: 58, 期号: 13, 页码: 6907-6915
作者:
Yang, Yinghe
;
Luo, Zixiong
;
Yang, Jin
;
Liang, Xudong
;
Song HX(宋恒旭)
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/18
Fracture Characteristics of Granite Specimens after Heating-Cooling treatments: Insights from Experiments and GBM Simulations
期刊论文
OAI收割
COMPUTERS AND GEOTECHNICS, 2025, 卷号: 182, 页码: 17
作者:
Yin, Hao
;
Huang, Yan-Hua
;
Zhang, Kun-Bo
;
Liu, Xue-Wei
;
Peng, Jun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/06/27
Granite
EGS
Thermal cycling
Fracture toughness
GBM
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/05/27
Coal-rock interface real-time recognition based on the improved YOLO detection and bilateral segmentation network
期刊论文
OAI收割
UNDERGROUND SPACE, 2025, 卷号: 21, 页码: 22-43
作者:
Xu, Shuzhan
;
Jiang, Wanming
;
Liu, Quansheng
;
Wang, Hongsheng
;
Zhang, Jun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/27
Coal-rock real-time recognition
Grayscale enhancement
YOLO
Bilateral segmentation network
Edge inference
Comprehensive Evidence That Detecting Urban Signals in Large-Scale Warming Is Highly Uncertain
期刊论文
OAI收割
GEOPHYSICAL RESEARCH LETTERS, 2025, 卷号: 52, 期号: 5, 页码: e2025GL115032
作者:
Shen, Pengke
;
Zhao, Shuqing
;
Xu, Zhiyu
;
Zhang, Xueqin
;
Lu, Bo
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/04/21
urbanization
warming trends
temporal asymmetry
contribution
nonlinearity