中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [33]
广州能源研究所 [7]
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期刊论文 [63]
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Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 18, 页码: 15469-15481
作者:
Wu, Xinyuan
;
Pan, Jiayi
;
Fan, Rufeng
;
Zhang, Yiwei
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/06/23
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Wu, Xinyuan
;
Li, Shunyao
;
Liang, Ting
;
Yu, Qing
;
Zhang, Yiwei
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/06/23
Activity-based protein profiling data
Covalent DNA-encoded chemical library
Covalent ligand selection
Lysine-targeting covalent inhibitors
GENNDTI: Drug-Target Interaction Prediction Using Graph Neural Network Enhanced by Router Nodes
期刊论文
OAI收割
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2024, 卷号: 28, 期号: 12, 页码: 7588-7598
作者:
Yang, Beiyuan
;
Liu, Yule
;
Wu, Junfeng
;
Bai, Fang
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/01/14
DTI
interpretability
graph enhancement
prior knowledge
graph neural network
DTI
interpretability
graph enhancement
prior knowledge
graph neural network
miCGR: interpretable deep neural network for predicting both site-level and gene-level functional targets of microRNA
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 26, 期号: 1, 页码: 13
作者:
Wu, Xiaolong
;
Zhang, Lehan
;
Tong, Xiaochu
;
Wang, Yitian
;
Zhang, Zimei
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/25
MicroRNA
target prediction
chaos game representation
deep learning
convolutional neural network
Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14
作者:
Wang, Xudong
;
Xiong, Liwei
;
Zhu, Ying
;
Liu, Sixiu
;
Zhao, Wenfeng
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/12/25
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 15
作者:
Liu, Yadan
;
Ye, Jialin
;
Fan, Zisheng
;
Wu, Xiaolong
;
Zhang, Yinghui
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/12/16
cGAS-STING signaling
Ginkgetin
senescence
STING inhibitor
target identification
Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 12
作者:
Suo, Yanrui
;
Qian, Xu
;
Xiong, Zhaoping
;
Liu, Xiaohong
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2024/11/26
Identifying compound-protein interactions with knowledge graph embedding of perturbation transcriptomics
期刊论文
OAI收割
CELL GENOMICS, 2024, 卷号: 4, 期号: 10, 页码: 100655
作者:
Ni, Shengkun
;
Kong, Xiangtai
;
Zhang, Yingying
;
Chen, Zhengyang
;
Wang, Zhaokun
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/06/04
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
期刊论文
OAI收割
CELL METABOLISM, 2024, 卷号: 36, 期号: 10, 页码: 25
作者:
Zhou, Bing
;
Luo, Yunchen
;
Bi, Hanqi
;
Zhang, Ni
;
Ma, Mingyue
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/11/26
Reducing overconfident errors in molecular property classification using Posterior Network
期刊论文
OAI收割
PATTERNS, 2024, 卷号: 5, 期号: 6, 页码: 100991
作者:
Fan, Zhehuan
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/06/04