中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [24]
大连化学物理研究所 [14]
地理科学与资源研究... [12]
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期刊论文 [131]
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2025 [4]
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De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
Neural texture synthesis and style transfer of coal-rock images in coal mine heading faces using very deep convolutional networks
期刊论文
OAI收割
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY, 2025, 卷号: 157, 页码: 20
作者:
Xu, Shuzhan
;
Liu, Quansheng
;
Yu, Honggan
;
Huang, Xing
;
Bo, Yin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/27
Coal-rock recognition
Neural style transfer
Image synthesis
Region similarity transform
VGG network
Bilateral segmentation network
Luteolin alleviates olfactory dysfunction in eosinophilic chronic rhinosinusitis through modulation of the TLR4/NF-κB signaling pathway
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2025, 卷号: 148, 页码: 15
作者:
Shi, Jiali
;
Dai, Li
;
Gu, Jun
;
Liu, Lu
;
Chen, Yunhua
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/04/01
Luteolin
ECRS
TLR4/NF-kappa B signaling pathway
Olfactory dysfunction
Fully superhydrophobic porous medium with super durability
期刊论文
OAI收割
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2024, 卷号: 702, 页码: 135108
作者:
Ju, Haolin
;
Li PL(李培柳)
;
Zhao, Yiming
;
Liu, Liyang
;
Zhan, Fei
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/12/02
Fully superhydrophobic bulk
Abrasion
Durability
Porous medium
Anti-icing
Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer
期刊论文
OAI收割
NANO TODAY, 2024, 卷号: 58, 页码: 12
作者:
Zhang, Huijuan
;
Chen, Fangmin
;
Cheng, Wenhao
;
Lai, Yi
;
Hou, Bo
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/10/09
Polyphenol
Cuproptosis
Dynamic covalent bond
Cancer metalloimmunotherapy
Tumor immune microenvironment
Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers
期刊论文
OAI收割
NATURE CANCER, 2024, 卷号: 5, 期号: 9, 页码: 39
作者:
Dong, Baijun
;
Xu, Jun-Yu
;
Huang, Yuqi
;
Guo, Jiacheng
;
Dong, Qun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
Size, distribution, and vulnerability of the global soil inorganic carbon
期刊论文
OAI收割
SCIENCE, 2024, 卷号: 384, 期号: 6692, 页码: 233-239
作者:
Huang, Yuanyuan
;
Song, Xiaodong
;
Wang, Ying-Ping
;
Canadell, Josep G.
;
Luo, Yiqi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/08/22
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 6, 页码: 4855-4869
作者:
Gu, Chenming
;
Liu, Jiayuan
;
Qian, Fei
;
Yu, Wenchao
;
Huang, Doudou
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/07
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415