中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:
Zheng, Fuqiang
;
Hu, Zhengtao
;
Chen, Hai
;
Cheng, Jiaxin
;
Hou, Qiongqiong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/06/23
Heterocycle-fused phenylcyclohexylamines
Multi-target antagonists
NMDAR
Monoamine transporter
Antidepressants
Study of ultra-high-energy gamma-ray source 1LHAASO J0056+6346u and its possible origins
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 7
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2025/06/10
gamma rays
cosmic rays
supernova remnant
young massive cluster
pulsar
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 22, 页码: 11
作者:
Xu, Jiuyin
;
Wu, Yanli
;
Xu, Youwei
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
prostaglandin D2 receptor 1
receptor activation
drug design
A pulsar-helium star compact binary system formed by common envelope evolution
期刊论文
OAI收割
SCIENCE, 2025, 卷号: 388, 期号: 6749, 页码: 859-863
作者:
Yang, Z. L.
;
Han, J. L.(1,2*)
;
Zhou, D. J.
;
Jing, W. C.
;
Chen, W. C.
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/06/04
Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885
作者:
Hou, Hui
;
Zhou, Jingyi
;
Sui, Qibang
;
Zhang, Changfa
;
Su, Zhaoming
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/07/25
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Screening and preparation of nanobodies for SIGLEC-15 detection
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2025, 卷号: 229, 页码: 9
作者:
Zhao, Shuaiying
;
Li, Lingyun
;
Lan, Zhongyun
;
Hou, Xiangyun
;
Huang, Ruimin
  |  
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2025/04/01
SIGLEC-15
Nanobody
Expression
Purification
Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling
期刊论文
OAI收割
ORGANIC LETTERS, 2025, 卷号: 27, 期号: 18, 页码: 4753-4761
作者:
Ma, Xiaolong
;
Miao, Erfei
;
Sun, Yili
;
Sun, Longkang
;
Huang, Chaoying
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/06/23
Synergistic Zn-Cd Bimetallic Engineering in ZIFs for High-Chloride 2e
-
ORR to H
2
O
2
in Simulated Neutral Seawater
期刊论文
OAI收割
MATERIALS, 2025, 卷号: 18, 期号: 8, 页码: 10
作者:
Wang, Xu
;
Wang, Nan
;
Liu, Kunpeng
;
Yang, Meinan
;
Zhang, Ruiyong
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/07/11
oxygen reduction reaction
neutral condition
electrocatalysis
H2O2
seawater