中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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高能物理研究所 [65]
上海药物研究所 [20]
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期刊论文 [125]
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Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17
作者:
Zhuang, Zhen
;
Miao, Yu-Ling
;
Song, Shan-Shan
;
Leng, Guang-Tong
;
Zhang, Xiao-Fei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/26
USP7 inhibitor
Structure-activity relationships
Anti-cancer
pyrrolo[2,3-d]pyrimidin-4-one
Contrasting characteristics and drivers of dry and warm snow droughts in China 's largest inland river basin
期刊论文
OAI收割
JOURNAL OF HYDROLOGY-REGIONAL STUDIES, 2024, 卷号: 53, 页码: 25
作者:
Wang, Zhixia
;
Huang, Shengzhi
;
Singh, Vijay P.
;
Mu, Zhenxia
;
Leng, Guoyong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/07/24
Dry-type and warm-type snow droughts
Snow drought characteristics and dynamics
Optimal parameters-based geographical detec-tor model
Random forest
Ocean-atmosphere couplings strength
A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15
作者:
Sun, Kai
;
Zhu, Nan-lin
;
Huang, Su-ling
;
Qu, Hui
;
Gu, Yi-pei
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/07/12
nonalcoholic steatohepatitis
THR beta agonists
resmetirom
bile acids composition
intestinal lipid absorption
Relative humidity and solar radiation exacerbate snow drought risk in the headstreams of the Tarim River
期刊论文
OAI收割
ATMOSPHERIC RESEARCH, 2024, 卷号: 297, 页码: 18
作者:
Wang, Zhixia
;
Huang, Shengzhi
;
Mu, Zhenxia
;
Leng, Guoyong
;
Duan, Weili
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/01/02
Snow drought risk
Copula function
Equitable threat score
Multivariable return period
Dynamic drought risk
Continental Tip With Thinned Lithosphere and Thickened Crust Is a Favorable Location for Subduction Initiation
期刊论文
OAI收割
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH, 2023, 卷号: 128, 期号: 8, 页码: 16
作者:
Zhang, Shengxing
;
Leng, Wei
;
Chen, Ling
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/28
geodynamic modeling
numerical simulation
subduction initiation
tectonics
Interaction-based transcriptome analysis via differential network inference
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2022, 页码: 11
作者:
Leng, Jiacheng
;
Wu, Ling-Yun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/02/07
differential network inference
differential expression analysis
interaction-based transcriptome analysis
Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors
期刊论文
OAI收割
Natural Products and Bioprospecting, 2022, 卷号: 12, 期号: 1
作者:
Deng,Xu
;
Huang,Su-Ling
;
Ren,Jian
;
Pan,Zheng-Hong
;
Shen,Yu
  |  
收藏
  |  
浏览/下载:39/0
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提交时间:2022/11/11
Metabolic syndrome
Tanshinones
Selective 11β-HSD1 inhibitors
Structure–activity relationships
Development and structure-activity relationships of tanshinones as selective 11beta-hydroxysteroid dehydrogenase 1 inhibitors
期刊论文
OAI收割
Natural products and bioprospecting, 2022, 卷号: 12, 期号: 1, 页码: 36
作者:
Deng, Xu
;
Huang, Su-Ling
;
Ren, Jian
;
Pan, Zheng-Hong
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/15
Metabolic syndrome
Selective 11beta-HSD1 inhibitors
Structure-activity relationships
Tanshinones
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 14
作者:
Huang, Su-Ling
;
Xie, Wei
;
Ye, Yang-Liang
;
Liu, Jia
;
Qu, Hui
  |  
收藏
  |  
浏览/下载:47/0
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提交时间:2022/11/11
type 2 diabetes mellitus
coronarin A
glycogen synthesis
gluconeogenesis
mTORC1
IRS1
Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus
期刊论文
OAI收割
JOURNAL OF NATURAL PRODUCTS, 2022, 卷号: 85, 期号: 8, 页码: 2090-2099
作者:
Zhou, Jun-Su
;
Huang, Su-Ling
;
Gao, Yuan
;
Liu, Qun-Fang
;
Leng, Ying
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/09/30