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浏览/检索结果: 共297条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307 作者:  Sun, Mingyang;  Chen, Beijing;  Teng, Dan;  Zhao, Hongshen;  Liao, Yilie   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21 作者:  Sui, Qibang;  Zhou, Yuanyang;  Li, Manjia;  Wang, Dan;  Cui, Rongrong   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/12/25 Synthetic lethal  MSI tumors  WRN inhibitors  Triazolo-pyrimidine derivatives   2-(1-Phenylvinyl)benzoic acid as a highly active leaving group for metal-free glycosylation 期刊论文  OAI收割 ORGANIC CHEMISTRY FRONTIERS, 2025, 页码: 7 作者:  Dai, Qi;  Li, Penghua;  Cao, Yaran;  Xie, Xiangying;  Zhang, Chen   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/04/01 Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy 期刊论文  OAI收割 CANCER MEDICINE, 2025, 卷号: 14, 期号: 1, 页码: 13 作者:  Wang, Kun;  Zhang, Yingying;  Su, Zhaoming;  Wang, Bei;  Zhou, Yuanyang   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/04/01 biomarker  CDC42  clinical response  immunotherapy  pan-cancer   FAPM: functional annotation of proteins using multimodal models beyond structural modeling 期刊论文  OAI收割 BIOINFORMATICS, 2024, 卷号: 40, 期号: 12, 页码: 12 作者:  Xiang, Wenkai;  Xiong, Zhaoping;  Chen, Huan;  Xiong, Jiacheng;  Zhang, Wei   |  收藏  |  浏览/下载：94/0  |  提交时间：2025/01/14 Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity 期刊论文  OAI收割 NATURE AGING, 2024, 卷号: 4, 期号: 12, 页码: 1828-+ 作者:  Pei, Siyu;  Deng, Xiuyu;  Yang, Ruirui;  Wang, Hui;  Shi, Jian-Hong   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/02/28 SurfDock is a surface-informed diffusion generative model for reliable and accurate protein-ligand complex prediction 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 24 作者:  Cao, Duanhua;  Chen, Mingan;  Zhang, Runze;  Wang, Zhaokun;  Huang, Manlin   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/01/06 miCGR: interpretable deep neural network for predicting both site-level and gene-level functional targets of microRNA 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 26, 期号: 1, 页码: 13 作者:  Wu, Xiaolong;  Zhang, Lehan;  Tong, Xiaochu;  Wang, Yitian;  Zhang, Zimei   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/12/25 MicroRNA  target prediction  chaos game representation  deep learning  convolutional neural network   Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Chen, Beijing;  Sun, Mingyang;  Zhang, Chun;  Huang, Qi;  Teng, Dan   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/12/25