中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [60]
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期刊论文 [131]
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Discovery, Optimization, and Evaluation of Novel Pyridin-2(1
H
)-one Analogues as Potent TRK Inhibitors for Cancer Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183
作者:
Xu, Zichao
;
Peng, Xia
;
Zhang, Renjie
;
Ji, Yinchun
;
You, Mengke
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/27
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Gu, Yuejiao
;
Ge, Zhiming
;
Tao, Zhaofan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/27
Targeting ST8SIA6-AS1 counteracts KRAS
G12C
inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22
作者:
Wang, Yafang
;
Yao, Mingyue
;
Li, Cheng
;
Yang, Kexin
;
Qin, Xiaolong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
KRAS(G12C)
c-Myc
PLK1
LncRNA
ST8SIA6-AS1
Drug resistance
Precise measurement method of carrier motion state in microgravity environment
期刊论文
OAI收割
MEASUREMENT, 2023, 卷号: 222, 页码: 17
作者:
Liu, Mingyue
;
Zhu, Huizhong
;
Xu, Xinchao
;
Ma, Youqing
;
Zhang, Shuo
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/28
Multi-camera calibration
Stereo vision
Extraction of homonymous points
Random Sample Consensus (RANSAC)
Carrier motion state
Structure-Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 9
作者:
Shen, Chang
;
Xu, Peijia
;
Zhang, Changfa
;
Su, Zhaoming
;
Shan, Bin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
cGAS-STING signaling pathway
STING agonists
antitumor immunity
anti-infection immunity
Erosion Performance of TiAlSiN Coatings Prepared by High-Power Pulsed Magnetron Sputtering
期刊论文
OAI收割
METALS, 2023, 卷号: 13, 期号: 7, 页码: 1306
作者:
Li, Hua
;
Li, Liuhe
;
Li, Duoduo
;
Tang, Ling
;
Luo, Yang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/09/05
erosion resistance
phase composition
TiAlSiN coating
discharge voltages
Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis
期刊论文
OAI收割
EMBO REPORTS, 2023, 卷号: 24, 期号: 4
作者:
Hao, Shumeng
;
Zhang, Sulin
;
Ye, Jialin
;
Chen, Lifan
;
Wang, Yan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
FAO
glycolysis
Goliath
inflammation
obesity
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214
作者:
Zhou, Zehui
;
Zhou, Guizhen
;
Zhou, Chuan
;
Fan, Zisheng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3327-3347
作者:
Shan, Bin
;
Hou, Hui
;
Zhang, Keke
;
Li, Rui
;
Shen, Chang
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2023
作者:
Cao, Yangyang
;
Liu, Xiaohui
;
Zhang, Jingjing
;
Liu, Zhongmin
;
Fu, Yan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
Alzheimer?s disease
fluorescent probe
imaging agent
Amyloid-?
coumarin