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浏览/检索结果: 共201条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors 期刊论文  OAI收割 SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18 作者:  Yang, Ruirui;  Wang, Bei;  Su, Zhaoming;  Song, Ying;  Zhang, Yingying   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/08/20 Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 11484-11501 作者:  Xu, Zichao;  Liu, Yueling;  Wang, Peng;  Peng, Xia;  Cheng, Jiawei   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/08/20 Palladium-Catalyzed Enantioselective Arylative Dearomatization of Naphthols and Phenols for Constructing Quinazoline-Containing Spirocycles 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 9 作者:  Zhang, Chiyue;  Xu, Gaoya;  Zhao, Wenlu;  Li, Xutong;  Zheng, Mingyue   |  收藏  |  浏览/下载：17/0  |  提交时间：2025/07/25 Antiproliferative activity  Catalytic asymmetric dearomatization  Palladium  Quinazoline-containing spirocycles  Three-dimensionality   Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885 作者:  Hou, Hui;  Zhou, Jingyi;  Sui, Qibang;  Zhang, Changfa;  Su, Zhaoming   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/07/25 Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer 期刊论文  OAI收割 NATURE IMMUNOLOGY, 2025, 卷号: 26, 期号: 5, 页码: 46 作者:  Zhu, Qingchen;  Zhang, Guiheng;  Cao, Ming;  Huang, Huan;  He, Dan   |  收藏  |  浏览/下载：26/0  |  提交时间：2025/06/23 Bridging chemistry and artificial intelligence by a reaction description language 期刊论文  OAI收割 NATURE MACHINE INTELLIGENCE, 2025, 卷号: 7, 期号: 5, 页码: 16 作者:  Xiong, Jiacheng;  Zhang, Wei;  Wang, Yinquan;  Huang, Jiatao;  Shi, Yuqi   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/07/25 Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer 期刊论文  OAI收割 NATURE CANCER, 2025, 页码: 37 作者:  Wang, Hanling;  Zhang, Sulin;  Pan, Qiang;  Guo, Jiacheng;  Li, Ni   |  收藏  |  浏览/下载：14/0  |  提交时间：2025/05/27 Geriatric Nutritional Risk Index is an effective prognostic predictor for metastatic/recurrent or unresectable esophageal cancer receiving immunotherapy 期刊论文  OAI收割 JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2025, 卷号: 16, 期号: 1, 页码: 22 作者:  Wang, Bei;  Wang, Zixuan;  Xu, Chuanhai;  Wang, Yueqin;  Gao, Honglan   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/05/27 Geriatric Nutritional Risk Index (GNRI)  esophageal squamous cell carcinoma (ESCC)  immune checkpoint inhibitors (ICIs)  programmed cell death ligand 1 (PD-L1)   IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19 作者:  Yao, Mingyue;  Yan, Wenzhong;  Wang, Yafang;  Zhao, Yu;  Xu, Xiaowei   |  收藏  |  浏览/下载：25/0  |  提交时间：2025/04/01 Acute myeloid leukemia  HDAC inhibitor  FLT3-ITD mutation  DNA damage response  Synergistic effect  Drug resistance   Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：36/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy