中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Detection of an Orphan X-Ray Flare from a Blazar Candidate EP240709a with the Einstein Probe
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 984, 期号: 1
作者:
Liu, Mingjun
;
Zhang, Yijia
;
Wang, Yun
;
Xue, Rui
;
Buckley, David
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/05/05
Late spring-early summer drought and soil properties jointly modulate two pine species' decline and climatic sensitivity in temperate Northern China
期刊论文
OAI收割
FOREST ECOSYSTEMS, 2025, 卷号: 12, 页码: 100273
作者:
Li, Yuheng
;
Fan, Zhaofei
;
Xu, Lihong
;
Zhang, Xiao
;
Shi, Zhongjie
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/02/24
Tree rings
Climate sensitivity
Growth decline
Global warming
Drought
Soil property
Anisotropic tensile behavior and fracture characteristics of an additively manufactured nickel alloy without and with a heat treatment of solution aging
期刊论文
OAI收割
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, 2025, 卷号: 927, 页码: 11
作者:
Xu SW(徐守文)
;
Pan, Sining
;
Li ZY(李志永)
;
Li SX(李少霞)
;
He XL(何秀丽)
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/03/21
Additive manufacturing
Ni-based superalloy
Anisotropy
Tensile fracture
Microstructure
Ductility
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
期刊论文
OAI收割
CELL RESEARCH, 2025, 卷号: 35, 期号: 4, 页码: 284-295
作者:
Sun, Demeng
;
Li, Xiang
;
Yuan, Qingning
;
Wang, Yuanxia
;
Shi, Pan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/05/27
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
期刊论文
OAI收割
NATURE CANCER, 2025, 页码: 37
作者:
Wang, Hanling
;
Zhang, Sulin
;
Pan, Qiang
;
Guo, Jiacheng
;
Li, Ni
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
Self-Oxygenating PROTAC Microneedle for Spatiotemporally-Confined Protein Degradation and Enhanced Glioblastoma Therapy
期刊论文
OAI收割
ADVANCED MATERIALS, 2025, 页码: 13
作者:
Jiang, Xingyu
;
Lai, Yi
;
Xia, Wenzheng
;
Yang, Wenfang
;
Wang, Junjue
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/24
acid-activatable photodynamic therapy
double-layered microneedle
glioblastoma therapy
light-activatable PROTAC prodrug
protein degradation
Science objectives of the Einstein Probe mission
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 3
作者:
Yuan, Weimin
;
Dai, Lixin
;
Feng, Hua
;
Jin, Chichuan
;
Jonker, Peter
  |  
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2025/02/13
Einstein Probe
X-ray astronomy
X-ray telescopes
time-domain astronomy
transients
variability
Science objectives of the Einstein Probe mission
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 3, 页码: 239501
作者:
Yuan, Weimin
;
Dai, Lixin
;
Feng, Hua
;
Jin, Chichuan
;
Jonker, Peter
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/02/27
Einstein Probe
X-ray astronomy
X-ray telescopes
time-domain astronomy
transients
variability
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19
作者:
Yao, Mingyue
;
Yan, Wenzhong
;
Wang, Yafang
;
Zhao, Yu
;
Xu, Xiaowei
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Acute myeloid leukemia
HDAC inhibitor
FLT3-ITD mutation
DNA damage response
Synergistic effect
Drug resistance