中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [43]
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期刊论文 [211]
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生命有机化学 [7]
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Discovery of CZL-046 with an (
S
)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 20, 页码: 18606-18628
作者:
Chen, Zonglong
;
Yang, Hong
;
Zhang, Yan
;
Lyu, Xiaodong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/05
Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads
期刊论文
OAI收割
COMMUNICATIONS CHEMISTRY, 2024, 卷号: 7, 期号: 1, 页码: 10
作者:
Dong, Sanfeng
;
Huang, Hui
;
Li, Jintian
;
Li, Xiaomei
;
Bunu, Samuel Jacob
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/21
Vertical variations of bacteriohopanepolyols near the Changjiang Estuary waters: Implications for marine hypoxia and bacterial activities
期刊论文
OAI收割
CHEMICAL GEOLOGY, 2024, 卷号: 651, 页码: 14
作者:
Yin, Meiling
;
Duan, Liqin
;
Song, Jinming
;
Kan, Jiawei
;
Yuan, Huamao
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/06/04
Bacteriohopanepolyols (BHPs)
Preservation
Seawater hypoxia
Anammox
Functional genes
The Changjiang Estuary waters
Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486
作者:
Chang, Qi
;
Li, Jiayi
;
Deng, Yue
;
Zhou, Ruilin
;
Wang, Bingwei
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/03/25
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17
作者:
Zhu, Yueyue
;
Liu, Bo
;
Chen, Zonglong
;
Wang, Xianyang
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/12/08
Toll -like receptor 2/6 agonists
PamCS
Structure-activity relationship
Lipopeptide
Immunostimulants
Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 5
作者:
Wang, Yujie
;
Xu, Keshi
;
Liu, Hongchun
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/12/19
Auristatin E
beta-Glucuronidase
Antiproliferation
Tumor microenvironment
The first record of Lower Cretaceous theropod tracks in Turpan-Hami Basin, Xinjiang, northwestern China
期刊论文
OAI收割
HISTORICAL BIOLOGY, 2023, 页码: 6
作者:
Li, Yang
;
Jiang, Shunxing
;
Yan, Feng
;
Ma, Yingxia
;
Wang, Xiaolin
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/11/02
Theropod tracks
Lower Cretaceous
Hami pterosaur fauna
Turpan-Hami Basin
Xinjiang
Geology, geochronology, and geochemistry of the Gaojiabang tungsten-molybdenum deposit, Anhui Province, Southeast China
期刊论文
OAI收割
ORE GEOLOGY REVIEWS, 2023, 卷号: 157, 页码: 28
作者:
Zheng, Fangshun
;
Qin, Kezhang
;
Cook, Nigel J.
;
Li, Guangming
;
Ciobanu, Cristiana L.
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/12/29
Gaojiabang
Alteration stages
Porphyry-skarn type deposit
W-Mo mineralization
Ductile deformations
Qingyang-Jiuhua Complex
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16
作者:
He, Yulong
;
Li, Shunyi
;
Zhu, Yueyue
;
Wang, Yujie
;
Chen, Yuqi
  |  
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2023/10/17
Structure-activity relationship
FABP4 inhibitor
Biphenyl scaffold
Selectivity
Oral bioavailability
Anti-inflammation