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Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Deciphering multi-media occurrence and anthropogenic drivers of potentially toxic elements in a rapidly urbanized estuary: A neural network-enhanced source apportionment
期刊论文
OAI收割
MARINE POLLUTION BULLETIN, 2025, 卷号: 218, 页码: 118178
作者:
Wang, Weili
;
Lin, Yuhong
;
Pan, Zhong
;
Liu, Yang
;
Wang, Lingqing
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/18
Bioaccumulation
Pollution characteristics
Multimedia
Ecological risk
Source
An overview of PROTACs targeting KRAS and SOS1 as antitumor agents
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 13
作者:
Han, Zhiqiu
;
Wu, Qianping
;
Rao, Hongxin
;
Xu, Tianfeng
;
Zhou, Chuan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
KRAS
SOS1
PROTAC
Antitumor agent
Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors
期刊论文
OAI收割
ADVANCED DRUG DELIVERY REVIEWS, 2025, 卷号: 224, 页码: 27
作者:
Zhang, Ping
;
Pan, Jiaxing
;
Lin, Shutong
;
Peng, Bo
;
An, Caiyan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Pancreatic cancer
Cancer immune cycle
Immune resistance
Drug delivery systems
Stimuli-responsive
Engineering of Sono-Activatable Immunogels for Immunometabolism Disorder Normalization Therapy of Breast Cancer
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 26, 页码: 22412-22426
作者:
Guo, Yu
;
Pan, Jiaxing
;
Wang, Junjue
;
Zhang, Huijuan
;
Yang, Wenfang
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 11484-11501
作者:
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Detection of an Orphan X-Ray Flare from a Blazar Candidate EP240709a with the Einstein Probe
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 984, 期号: 1
作者:
Liu, Mingjun
;
Zhang, Yijia
;
Wang, Yun
;
Xue, Rui
;
Buckley, David
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/05/05
Late spring-early summer drought and soil properties jointly modulate two pine species' decline and climatic sensitivity in temperate Northern China
期刊论文
OAI收割
FOREST ECOSYSTEMS, 2025, 卷号: 12, 页码: 100273
作者:
Li, Yuheng
;
Fan, Zhaofei
;
Xu, Lihong
;
Zhang, Xiao
;
Shi, Zhongjie
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2025/02/24
Tree rings
Climate sensitivity
Growth decline
Global warming
Drought
Soil property
Anisotropic tensile behavior and fracture characteristics of an additively manufactured nickel alloy without and with a heat treatment of solution aging
期刊论文
OAI收割
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, 2025, 卷号: 927, 页码: 11
作者:
Xu SW(徐守文)
;
Pan, Sining
;
Li ZY(李志永)
;
Li SX(李少霞)
;
He XL(何秀丽)
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/03/21
Additive manufacturing
Ni-based superalloy
Anisotropy
Tensile fracture
Microstructure
Ductility