中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Qualitative and quantitative determination of SIPI-2011 and its two major metabolites in human plasma
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 264, 页码: 11
作者:
Fang, Jie
;
Jing, Jiao
;
Li, Guangyao
;
Wang, Yongbin
;
Zhao, Binjiang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SIPI-2011
UPLC-UV/Q-TOF
LC-MS/MS
Metabolic Profiling
Pharmacokinetics
Human gut
Bifidobacterium longum
subsp.
suillum
is enriched in vitro by a pectic polysaccharide isolated from the flowers of
Lilium lancifolium
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 364, 页码: 14
作者:
Li, Meixia
;
Liu, Renjie
;
Wang, Tao
;
Duo, Lana
;
Chen, Guo
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Polysaccharides
Lilium lancifolium
Human gut microbiota
Bifidobacterium longum subsp. suillum
Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2025, 卷号: 16, 页码: 13
作者:
Bai, Yang
;
Wang, Rui
;
Jin, Can
;
Wang, Lili
;
Tang, Yun
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/06/23
Dendrobium nobile Lindl
retina
oxygen-induced retinopathy
vascular endothelial growth factor
Identifying the spatiotemporal patterns and natural and socioeconomic influencing factors of PM2.5 and O3 pollution in China
期刊论文
OAI收割
PLOS ONE, 2025, 卷号: 20, 期号: 2, 页码: e0317691
作者:
Zhan, Dongsheng
;
Wang, Zichen
;
Xiang, Hongyang
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2025/04/21
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
Peptidoglycan isolated from the fruit of
Lycium barbarum
alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Nie, Ying-min
;
Zhou, Wan-qi
;
Niu, Ting
;
Mao, Meng-fei
;
Zhan, Yu-xue
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/04/01
liver fibrosis
Lycium barbarum
peptidoglycan
LBPW
TGF-beta/Smad7
Akkermansia muciniphila
Structural elucidation of an active arabinoglucan from
Gomphrena
globosa
and its protection effect and mechanism against metabolic dysfunction-associated steatohepatitis
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 348, 页码: 15
作者:
Chen, Meilin
;
Zong, Jianing
;
He, Fei
;
Zhou, Wanqi
;
Liu, Renjie
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/12/11
Arabinoglucan
Gomphrena globosa
MASH
Thioredoxin
Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20
作者:
Luo, Menglan
;
Ye, Yunfei
;
Tang, Lu
;
Kan, Weijuan
;
Chen, Lin
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/11/26
Menin
Covalent inhibitor
Antitumor
Degradation
Numerical simulation of the unique rotating arc behaviors during narrow-groove GTAW
期刊论文
OAI收割
JOURNAL OF MANUFACTURING PROCESSES, 2024, 卷号: 131
作者:
Li, Kan
;
Jia, Chuanbao
;
Fang, Chao
;
Hu, Jiakun
;
Xu, Shichang
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2024/11/20
Numerical simulation
Rotating arc
Narrow-groove GTAW
Arc behaviors
Titanium alloy