中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14
作者:
Chen, Yu-jun
;
Zhao, Yu
;
Yao, Ming-yue
;
Wang, Ya-fang
;
Ma, Ming
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
acute myeloid leukemia
FLT3
p300/CBP
quizartinib resistance
combination strategy
De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2025, 卷号: 503, 页码: 13
作者:
Gao, Jialu
;
Zhu, Hua
;
Cai, Huanhuan
;
Ding, Qihang
;
Xiong, Xiaoxing
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/02/28
siRNA delivery
Atheromatous plaques
NIR-II imaging
Multifunctional nanoplatform
Epsin1/2
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12, 页码: 20
作者:
Wang, Hua
;
Tang, Shijie
;
Wu, Qibiao
;
He, Yayi
;
Zhu, Weikang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/02/28
EGFR-mutant lung cancer
adeno-to-squamous transition
tyrosine kinase inhibitor resistance
transcription factor network
RAPGEF3
π-HuB: the proteomic navigator of the human body
期刊论文
OAI收割
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:
He, Fuchu
;
Aebersold, Ruedi
;
Baker, Mark S.
;
Bian, Xiuwu
;
Bo, Xiaochen
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Emerging Pollutants
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2024, 卷号: 36, 期号: 11, 页码: 1607-1784
作者:
Wang, Yawei
;
Zhang, Qiurui
;
Yu, Nanyang
;
Wang, Yuan
;
Wei, Si
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/03
emerging pollutants
occurrence level
environmental behavior
ecological risks
control strategies
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20531-20558
作者:
Hu, Shiliang
;
Tong, Linjiang
;
Qin, Qiao
;
Wen, Jiaxin
;
Li, Yan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/11
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
期刊论文
OAI收割
CELL METABOLISM, 2024, 卷号: 36, 期号: 10, 页码: 25
作者:
Zhou, Bing
;
Luo, Yunchen
;
Bi, Hanqi
;
Zhang, Ni
;
Ma, Mingyue
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/11/26
Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 12
作者:
Li, Yang
;
Yuan, Qingning
;
He, Xinheng
;
Zhang, Yumu
;
You, Chongzhao
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 14
作者:
Li, Fang-lin
;
Gu, Long-hua
;
Tong, Yong-liang
;
Chen, Run-qiu
;
Chen, Shi-yi
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/10/21
cancer immunotherapy
INHBA
Activin A
IFN-gamma signaling pathway
PD-L1