中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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沈阳应用生态研究所 [48]
西北高原生物研究所 [38]
武汉病毒研究所 [19]
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期刊论文 [192]
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Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12735-12759
作者:
Liu, Zhi
;
Jiang, Kailong
;
Liu, Yan
;
Li, Junfei
;
Huang, Siqi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/26
Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287
作者:
Hu, Linghao
;
Li, Huiyun
;
Qin, Junlin
;
Yang, Dan
;
Liu, Jieming
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2024/02/27
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12
作者:
Tang, Shuai
;
Duan, Yichen
;
Yuan, Tao
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/12/11
KRAS
Pancreatic ductal adenocarcinoma
MAPK pathway
Tetrandrine
TRAIL
Death receptors
Computing the relative binding affinity of ligands based on a pairwise binding comparison network
期刊论文
OAI收割
Nature computational science, 2023, 卷号: 3, 期号: 10, 页码: 860-872
作者:
Yu, Jie
;
Li, Zhaojun
;
Chen, Geng
;
Kong, Xiangtai
;
Hu, Jie
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/26
A small extent of seawater intrusion significantly enhanced Cd uptake by rice in coastal paddy fields
期刊论文
OAI收割
JOURNAL OF HAZARDOUS MATERIALS, 2023, 卷号: 458, 页码: 13
作者:
Chi, Wenting
;
Chen, Guojun
;
Hu, Shiwen
;
Li, Xiaomin
;
Cheng, Kuan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/23
Cadmium
Salinity
Rice
Redox
Seawater intrusion
The key roles of Fe oxyhydroxides and humic substances during the transformation of exogenous arsenic in a redox-alternating acidic paddy soil
期刊论文
OAI收割
WATER RESEARCH, 2023, 卷号: 242, 页码: 11
作者:
Hong, Zebin
;
Hu, Shiwen
;
Yang, Yang
;
Deng, Ziwei
;
Li, Xiaomin
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/08/23
Paddy soil
Exogenous arsenic
Fe oxyhydroxides
Humic substances
Kinetic model
Automated pattern generation for swarm robots using constrained multi-objective genetic programming
期刊论文
OAI收割
SWARM AND EVOLUTIONARY COMPUTATION, 2023, 卷号: 81
作者:
Fan, Zhun
;
Wang, Zhaojun
;
Li, Wenji
;
Zhu, Xiaomin
;
Hu, Bingliang
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/07/17
Gene regulatory network (GRN)
Entrapping pattern generation
Self-organization
Constrained multi-objective genetic
programming (CMOGP)
Modeling the effects of global cooling and the Tethyan Seaway closure on North African and South Asian climates during the Middle Miocene Climate Transition
期刊论文
OAI收割
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY, 2023, 卷号: 619, 页码: 12
作者:
Zhang, Jian
;
Hu, Yongyun
;
Zhu, Chenguang
;
Flogel, Sascha
;
Fang, Xiaomin
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/01/02
South Asian monsoon
Sahara desert
Middle Miocene Climate Optimum
Paleoclimate modeling
VG-Swarm: A Vision-Based Gene Regulation Network for UAVs Swarm Behavior Emergence
期刊论文
OAI收割
IEEE Robotics and Automation Letters, 2023, 卷号: 8, 期号: 3, 页码: 1175-1182
作者:
Li, Huanlin
;
Cai, Yuwei
;
Hong, Juncao
;
Xu, Peng
;
Cheng, Hui
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/02/28
Aerial systems
Perception and autonomy
biologically-inspired robots
swarm robotics
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15
作者:
Yu, Xiaolu
;
Long, Yiru
;
Chen, Binfan
;
Tong, Yongliang
;
Shan, Mengwen
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2022/12/13
PD-L1
TLR7
nanobody-drug-conjugate
cancer immunotherapy