中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [17]
上海光学精密机械研究... [5]
近代物理研究所 [4]
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:
Chen, Jiexuan
;
Wu, Mingfei
;
Mo, Jun
;
Hong, Ju
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/04/01
Discovery of N-Benzylpiperidinol derivatives as USP7 inhibitors against Hematology
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 13
作者:
Pan, Youlu
;
Chen, Haifeng
;
Fu, Jingfeng
;
Zhang, Jingyu
;
Wang, Peipei
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10
作者:
Yu, Qian
;
Gao, Lixin
;
Xu, Linhao
;
Han, Yubing
;
Cao, Yu
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/12/11
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28
作者:
Duan, Haiting
;
Zhang, Jingyu
;
Gui, Renzhao
;
Lu, Yang
;
Pang, Ao
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/08/20
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 21
作者:
Lu, Yang
;
Gao, Jian
;
Wang, Peipei
;
Chen, Haifeng
;
He, Xinjun
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/07/12
Hepatocellular carcinoma
Ubiquitin-specific protease 10
Deubiquitination
Selectivity
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:
Zhang, Jingyu
;
Duan, Haiting
;
Gui, Renzhao
;
Wu, Mingfei
;
Shen, Liteng
  |  
收藏
  |  
浏览/下载:153/0
  |  
提交时间:2023/12/19
Acute myeloid leukemia
Bromodomain-containing protein 9
Proteolysis-targeting chimera
Orally bioavailable
Docking
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15
作者:
Zhu, Cheng-Liang
;
Luo, Xiaomin
;
Tian, Tian
;
Rao, Zijian
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/08/16
AKT
Protein kinase B
PROTAC
Chemical degrader
Rational design
Dissecting photosynthetic electron transport and photosystems performance in Jerusalem artichoke (Helianthus tuberosus L.) under salt stress
期刊论文
OAI收割
FRONTIERS IN PLANT SCIENCE, 2022, 卷号: 13, 页码: 10
作者:
Yan, Kun
;
Mei, Huimin
;
Dong, Xiaoyan
;
Zhou, Shiwei
;
Cui, Jinxin
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/11/07
chlorophyll fluorescence
delayed chlorophyll fluorescence
malondialdehyde
modulated 820 nm reflection
photoinhibition
Dissecting photosynthetic electron transport and photosystems performance in Jerusalem artichoke (Helianthus tuberosus L.) under salt stress
期刊论文
OAI收割
FRONTIERS IN PLANT SCIENCE, 2022, 卷号: 13, 页码: 10
作者:
Yan, Kun
;
Mei, Huimin
;
Dong, Xiaoyan
;
Zhou, Shiwei
;
Cui, Jinxin
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/11/15
chlorophyll fluorescence
delayed chlorophyll fluorescence
malondialdehyde
modulated 820 nm reflection
photoinhibition