中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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浏览/检索结果: 共27条,第1-10条 帮助

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Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528
作者:  
Guo, Yu;  Song, Yi;  Wang, Hanlin;  Lu, Yang;  Zhang, Jingyu
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Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 20, 页码: 21939-21961
作者:  
Lian, Xuanmin;  Gao, Yue;  Du, Wenjing;  Xu, Chengcheng;  Dong, Xiaowu
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Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 20, 页码: 21249-21281
作者:  
Jin, Yuheng;  Liao, Xueyan;  Zhang, Jingyu;  Duan, Haiting;  Xu, Ran
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23
作者:  
Yuan, Haibin;  Gao, Yue;  Wang, Peipei;  Dong, Xiaowu;  Li, Jia
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML) 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:  
Mo, Jun;  Wang, Yuxian;  Pan, Youlu;  Xiao, Qitao;  Zhao, Jinyi
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Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 19, 页码: 20180-20206
作者:  
Yu, Xiaoli;  Liao, Xueyan;  Zhang, Jingyu;  Wang, Hanlin;  Li, Xian
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Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 17
作者:  
Lu, Yang;  Wang, Wentao;  Yuan, Cheng;  Luo, Mengxin;  Wang, Peipei
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:  
Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong
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Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:  
Jin, Yuheng;  Qi, Xuxin;  Yu, Xiaoli;  Cheng, Xirui;  Chen, Boya
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Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:  
Chen, Jiexuan;  Wu, Mingfei;  Mo, Jun;  Hong, Ju;  Wang, Wei
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