中国科学院机构知识库网格
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YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-46
作者:
Ling-Chu Chang
;
Hui-Yi Lin
;
Meng-Tung Tsai
;
Ruey-Hwang Chou
;
Fang-Yu Lee
  |  
收藏
  |  
浏览/下载:318/0
  |  
提交时间:2017/07/24
Yc-1
Triple-negative Breast Cancer
Erk
Ezh2
C-cbl
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:
Jin, Yuheng
;
Qi, Xuxin
;
Yu, Xiaoli
;
Cheng, Xirui
;
Chen, Boya
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/06/23
HDAC7
PROTAC
Selectivity
Hematologic malignancies
Non-enzymatic function
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:
Chen, Jiexuan
;
Wu, Mingfei
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/04/01
Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10
作者:
Yu, Qian
;
Gao, Lixin
;
Xu, Linhao
;
Han, Yubing
;
Cao, Yu
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/12/11
Chiral Nanostructured Ag Films for Multicarbon Products from CO
2
Electroreduction
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146
作者:
Zhang, Wanning
;
Ai, Jing
;
Ouyang, Tianwei
;
Yu, Lu
;
Liu, Aokun
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/11/20
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28
作者:
Duan, Haiting
;
Zhang, Jingyu
;
Gui, Renzhao
;
Lu, Yang
;
Pang, Ao
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/08/20
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 21
作者:
Lu, Yang
;
Gao, Jian
;
Wang, Peipei
;
Chen, Haifeng
;
He, Xinjun
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/07/12
Hepatocellular carcinoma
Ubiquitin-specific protease 10
Deubiquitination
Selectivity
Cryo-EM structure of human HCN3 channel and its regulation by cAMP
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 卷号: 300, 期号: 6, 页码: 10
作者:
Yu, Bo
;
Lu, Qiuyuan
;
Li, Jian
;
Cheng, Xinyu
;
Hu, Han
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/12/11