中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [25]
合肥物质科学研究院 [16]
烟台海岸带研究所 [13]
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期刊论文 [178]
会议论文 [4]
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Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
CDK9
EZH2
Dual target inhibitor
DLBCL
Long-circulating enzyme-activated HSP90-targeted camptothecin derivatives
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2025, 卷号: 383, 页码: 16
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Su, Yi
;
Lu, Yingxin
;
Jin, Jiyu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/07/25
eHSP90
Camptothecin derivatives
Cathepsin B
Long-circulating
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:
Tang, Mingze
;
Zhou, Xuan
;
Shen, Qianqian
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/08/22
Receptor -interacting protein kinase 1
Histone deacetylases
Inhibitor
Molecular dynamics (MD) simulation
ADMET analysis
Investigating vertical distributions and photochemical indications of formaldehyde, glyoxal, and NO
2
from MAX-DOAS observations in four typical cities of China
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 954
作者:
Hong, Qianqian
;
Xing, Jingchen
;
Xing, Chengzhi
;
Yang, Baixue
;
Su, Wenjing
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/11/20
Formaldehyde
Glyoxal
VOCs sources
Ozone formation sensitivity
MAX-DOAS
Emerging Pollutants
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2024, 卷号: 36, 期号: 11, 页码: 1607-1784
作者:
Wang, Yawei
;
Zhang, Qiurui
;
Yu, Nanyang
;
Wang, Yuan
;
Wei, Si
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2025/04/03
emerging pollutants
occurrence level
environmental behavior
ecological risks
control strategies
Zinc ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction
期刊论文
OAI收割
ONCOGENE, 2024, 页码: 11
作者:
Wang, Kangjunjie
;
Chen, Min
;
Yan, Shukun
;
Han, Ying
;
Yuan, Huairui
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/11/26
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired
N
-Linked 2-Acetylpyrrole Cap
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 19, 页码: 26
作者:
Zhang, Han
;
Shen, Qianqian
;
Hu, Zhu
;
Wu, Pei-Qian
;
Chen, Yi
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/11/26
HDAC inhibitors
anti-cancer activity
natural products
pyrrole derivatives
molecular docking
molecular dynamics simulation
A brain-to-gut signal controls intestinal fat absorption
期刊论文
OAI收割
NATURE, 2024, 页码: 27
作者:
Lyu, Qianqian
;
Xue, Wenzhi
;
Liu, Ruixin
;
Ma, Qinyun
;
Kasaragod, Vikram Babu
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2024/11/26
Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1
期刊论文
OAI收割
ADVANCED SCIENCE, 2024
作者:
Ding, Ling
;
Guo, Hongjie
;
Zhang, Jie
;
Zheng, Mingming
;
Zhang, Wenjie
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/11/20
ABCB1
autophagy
ER retention
PD-L1
zosuquidar