机构

• 上海药物研究所 [22]
• 上海应用物理研究所 [3]

采集方式

• OAI收割 [25]

内容类型

• 期刊论文 [23]
• 会议论文 [2]

发表日期

• 2020 [1]
• 2019 [1]
• 2018 [3]
• 2016 [2]
• 2015 [2]
• 2014 [5]
• 更多

学科主题

筛选

浏览/检索结果: 共25条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15 作者:  Liu, Zehui;  Hu, Qian;  Wang, Wanyan;  Lu, Sisi;  Wu, Dang   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/12/24 Multiple sclerosis  DHODH  Piperine  Natural product   Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593 作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian   |  收藏  |  浏览/下载：36/0  |  提交时间：2020/07/01 Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells 期刊论文  OAI收割 HAEMATOLOGICA, 2018, 卷号: 103, 期号: 9, 页码: 1472-1483 作者:  Wu, Dang;  Wang, Wanyan;  Chen, Wuyan;  Lian, Fulin;  Lang, Li   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 irondysregulatesappprocessingaccompanyingwithsappacellularretentionandsecretaseinhibitioninratcorticalneurons 期刊论文  OAI收割 actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 177 作者:  Chen Yuting;  Chen Wuyan;  Huang Xiaotian;  Xu Yechun;  Zhang Haiyan   |  收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 iron  neurons  amyloid precursor protein  sAPPα  β-amyloid  β-secretase  Alzheimer's disease   Iron dysregulates APP processing accompanying with sAPPa cellular retention and β-secretase inhibition in rat cortical neurons 期刊论文  OAI收割 Acta Pharmacologica Sinica, 2018, 卷号: 39, 期号: 2, 页码: 177 作者:  Chen Yuting;  Chen Wuyan;  Huang Xiaotian;  Xu Yechun;  Zhang Haiyan   |  收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 iron  neurons  amyloid precursor protein  sAPPα  β-amyloid  β-secretase  Alzheimer's disease   Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 10, 页码: 5115-5120 作者:  Liu, Qiufeng;  Chen, Xinde;  Chen, Wuyan;  Yuan, Xiaojing;  Su, Haixia   |  收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Structure-Based Discovery of PDEs Inhibitors 期刊论文  OAI收割 CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 卷号: 16, 期号: 9, 页码: 917-933 作者:  Li, Li;  Chen, Wuyan;  Chen, Tiantian;  Ren, Jing;  Xu, Yechun   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 Crystal structure  Cyclic nucleotide signalling pathway  Family-selective inhibitor  Medicinal chemistry  Phosphodiesterases  Structure-based drug design   Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors 期刊论文  OAI收割 Bioorganic & medicinal chemistry, 2015, 卷号: 23, 期号: 9, 页码: 1963-74 作者:  Liu, Jian;  Chen, Wuyan;  Xu, Yechun;  Ren, Sumei;  Zhang, Wei   |  收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain 期刊论文  OAI收割 SCIENTIFIC REPORTS, 2015, 卷号: 5 作者:  Zhang, Huaqun;  Zhou, Chen;  Chen, Wuyan;  Xu, Yechun;  Shi, Yanhong   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 87, 页码: 765-781 作者:  Chen, Danqi;  Shen, Aijun;  Li, Jian;  Shi, Feng;  Chen, Wuyan   |  收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 HSP90  Fragment-based drug discovery  Crystallography